| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10014408 | HBV | ENSG00000163288.14 | protein_coding | GABRB1 | No | No | 2560 | P18505 X5DNL6 |
| TVIS10014409 | HBV | ENSG00000163288.14 | protein_coding | GABRB1 | No | No | 2560 | P18505 X5DNL6 |
| TVIS10032719 | HBV | ENSG00000163288.14 | protein_coding | GABRB1 | No | No | 2560 | P18505 X5DNL6 |
| TVIS10035001 | HBV | ENSG00000163288.14 | protein_coding | GABRB1 | No | No | 2560 | P18505 X5DNL6 |
| TVIS10032784 | HBV | ENSG00000163288.14 | protein_coding | GABRB1 | No | No | 2560 | P18505 X5DNL6 |
| TVIS10042340 | HBV | ENSG00000163288.14 | protein_coding | GABRB1 | No | No | 2560 | P18505 X5DNL6 |
| TVIS10042341 | HBV | ENSG00000163288.14 | protein_coding | GABRB1 | No | No | 2560 | P18505 X5DNL6 |
| TVIS30088128 | HIV | ENSG00000163288.14 | protein_coding | GABRB1 | No | No | 2560 | P18505 X5DNL6 |
| TVIS30087096 | HIV | ENSG00000163288.14 | protein_coding | GABRB1 | No | No | 2560 | P18505 X5DNL6 |
| TVIS30080929 | HIV | ENSG00000163288.14 | protein_coding | GABRB1 | No | No | 2560 | P18505 X5DNL6 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | GABRB1 |
|---|---|
| DrugBank ID | DB00431 |
| Drug Name | Lindane |
| Target ID | BE0002344 |
| UniProt ID | P18505 |
| Regulation Type | antagonist |
| PubMed IDs | 17139284; 17016423; 7885191; 12645305; 9530529; 7566682; 14635176; 8841090; 10592235; 12614680; 20600211 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Cole LM, Roush RT, Casida JE: Drosophila GABA-gated chloride channel: modified [3H]EBOB binding site associated with Ala-->Ser or Gly mutants of Rdl subunit. Life Sci. 1995;56(10):757-65.@@Sauviat MP, Pages N: [Cardiotoxicity of lindane, a gamma isomer of hexachlorocyclohexane]. J Soc Biol. 2002;196(4):339-48.@@Anand M, Agrawal AK, Rehmani BN, Gupta GS, Rana MD, Seth PK: Role of GABA receptor complex in low dose lindane (HCH) induced neurotoxicity: neurobehavioural, neurochemical and electrophysiological studies. Drug Chem Toxicol. 1998 Feb;21(1):35-46.@@Joy RM, Walby WF, Stark LG, Albertson TE: Lindane blocks GABAA-mediated inhibition and modulates pyramidal cell excitability in the rat hippocampal slice. Neurotoxicology. 1995 Summer;16(2):217-28.@@Bloomquist JR: Chloride channels as tools for developing selective insecticides. Arch Insect Biochem Physiol. 2003 Dec;54(4):145-56.@@Narahashi T: Neuronal ion channels as the target sites of insecticides. Pharmacol Toxicol. 1996 Jul;79(1):1-14.@@Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.@@Vale C, Fonfria E, Bujons J, Messeguer A, Rodriguez-Farre E, Sunol C: The organochlorine pesticides gamma-hexachlorocyclohexane (lindane), alpha-endosulfan and dieldrin differentially interact with GABA(A) and glycine-gated chloride channels in primary cultures of cerebellar granule cells. Neuroscience. 2003;117(2):397-403.@@Heusinkveld HJ, Thomas GO, Lamot I, van den Berg M, Kroese AB, Westerink RH: Dual actions of lindane (gamma-hexachlorocyclohexane) on calcium homeostasis and exocytosis in rat PC12 cells. Toxicol Appl Pharmacol. 2010 Oct 1;248(1):12-9. doi: 10.1016/j.taap.2010.06.013. Epub 2010 Jun 21. |
| Groups | Approved; Withdrawn |
| Direct Classification | Cyclohexyl halides |
| SMILES | Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H]1Cl |
| Pathways | |
| PharmGKB | PA164754914 |
| ChEMBL | CHEMBL15891 |
