Target Gene Table ▼
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS44029857HTLV-1ENSG00000183454.19protein_codingGRIN2ANoYes2903Q12879
TVIS44029075HTLV-1ENSG00000183454.19protein_codingGRIN2ANoYes2903Q12879
TVIS44001350HTLV-1ENSG00000183454.19protein_codingGRIN2ANoYes2903Q12879
TVIS44014323HTLV-1ENSG00000183454.19protein_codingGRIN2ANoYes2903Q12879
TVIS44014324HTLV-1ENSG00000183454.19protein_codingGRIN2ANoYes2903Q12879
TVIS44032271HTLV-1ENSG00000183454.19protein_codingGRIN2ANoYes2903Q12879
TVIS44017860HTLV-1ENSG00000183454.19protein_codingGRIN2ANoYes2903Q12879
TVIS44051295HTLV-1ENSG00000183454.19protein_codingGRIN2ANoYes2903Q12879
TVIS44042004HTLV-1ENSG00000183454.19protein_codingGRIN2ANoYes2903Q12879
TVIS44042003HTLV-1ENSG00000183454.19protein_codingGRIN2ANoYes2903Q12879
TCGA Plot Options ▼
Drug Information ▼
GeneGRIN2A
DrugBank IDDB00145
Drug NameGlycine
Target IDBE0000760
UniProt IDQ12879
Regulation Typeantagonist
PubMed IDs17360906; 17403555; 17513636; 17646495; 17405869; 11752352
CitationsLiu Y, Wong TP, Aarts M, Rooyakkers A, Liu L, Lai TW, Wu DC, Lu J, Tymianski M, Craig AM, Wang YT: NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. J Neurosci. 2007 Mar 14;27(11):2846-57.@@Domingues A, Almeida S, da Cruz e Silva EF, Oliveira CR, Rego AC: Toxicity of beta-amyloid in HEK293 cells expressing NR1/NR2A or NR1/NR2B N-methyl-D-aspartate receptor subunits. Neurochem Int. 2007 May;50(6):872-80. Epub 2007 Mar 7.@@Brosnan RJ, Yang L, Milutinovic PS, Zhao J, Laster MJ, Eger EI 2nd, Sonner JM: Ammonia has anesthetic properties. Anesth Analg. 2007 Jun;104(6):1430-3, table of contents.@@Milutinovic PS, Yang L, Cantor RS, Eger EI 2nd, Sonner JM: Anesthetic-like modulation of a gamma-aminobutyric acid type A, strychnine-sensitive glycine, and N-methyl-d-aspartate receptors by coreleased neurotransmitters. Anesth Analg. 2007 Aug;105(2):386-92.@@Gabra BH, Kessler FK, Ritter JK, Dewey WL, Smith FL: Decrease in N-methyl-D-aspartic acid receptor-NR2B subunit levels by intrathecal short-hairpin RNA blocks group I metabotropic glutamate receptor-mediated hyperalgesia. J Pharmacol Exp Ther. 2007 Jul;322(1):186-94. Epub 2007 Apr 3.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.
GroupsApproved; Nutraceutical; Vet_approved
Direct ClassificationAlpha amino acids
SMILESNCC(O)=O
Pathwaysgamma-Glutamyltranspeptidase Deficiency; Lesch-Nyhan Syndrome (LNS); Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency); Molybdenum Cofactor Deficiency; AICA-Ribosiduria; Purine Nucleoside Phosphorylase Deficiency; gamma-Glutamyltransferase Deficiency; Hyperprolinemia Type II; Glutamate Metabolism; Adenine Phosphoribosyltransferase Deficiency (APRT); Mercaptopurine Action Pathway; 2-Hydroxyglutric Aciduria (D and L Form); L-Arginine:Glycine Amidinotransferase Deficiency; Hyperinsulinism-Hyperammonemia Syndrome; Congenital Bile Acid Synthesis Defect Type II; Porphyrin Metabolism; Prolidase Deficiency (PD); Glycine and Serine Metabolism; Carnitine Synthesis; Adenosine Deaminase Deficiency; Methionine Metabolism; Bile Acid Biosynthesis; Hyperprolinemia Type I; Cystathionine beta-Synthase Deficiency; Arginine and Proline Metabolism; 27-Hydroxylase Deficiency; Sarcosine Oncometabolite Pathway; Purine Metabolism; Gout or Kelley-Seegmiller Syndrome; Ammonia Recycling
PharmGKBPA449789
ChEMBLCHEMBL773