| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30004718 | HIV | ENSG00000079999.14 | protein_coding | KEAP1 | No | Yes | 9817 | Q14145 |
| TVIS20020750 | HPV | ENSG00000079999.14 | protein_coding | KEAP1 | No | Yes | 9817 | Q14145 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | KEAP1 |
|---|---|
| DrugBank ID | DB12513 |
| Drug Name | Omaveloxolone |
| Target ID | BE0004756 |
| UniProt ID | Q14145 |
| Regulation Type | inhibitor |
| PubMed IDs | 29538645; 35052661 |
| Citations | Shekh-Ahmad T, Eckel R, Dayalan Naidu S, Higgins M, Yamamoto M, Dinkova-Kostova AT, Kovac S, Abramov AY, Walker MC: KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy. Brain. 2018 May 1;141(5):1390-1403. doi: 10.1093/brain/awy071.@@Parsons ALM, Bucknor EMV, Castroflorio E, Soares TR, Oliver PL, Rial D: The Interconnected Mechanisms of Oxidative Stress and Neuroinflammation in Epilepsy. Antioxidants (Basel). 2022 Jan 14;11(1):157. doi: 10.3390/antiox11010157. |
| Groups | Approved; Investigational |
| Direct Classification | Cyclohexenones |
| SMILES | CC(F)(F)C(=O)N[C@]12CCC(C)(C)C[C@H]1[C@H]1C(=O)C=C3[C@@]4(C)C=C(C#N)C(=O)C(C)(C)[C@@H]4CC[C@@]3(C)[C@]1(C)CC2 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL4303525 |
