| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10010538 | HBV | ENSG00000132763.15 | protein_coding | MMACHC | No | No | 25974 | A0A0C4DGU2 Q9Y4U1 |
| TVIS10009818 | HBV | ENSG00000132763.15 | protein_coding | MMACHC | No | No | 25974 | A0A0C4DGU2 Q9Y4U1 |
| TVIS10010539 | HBV | ENSG00000132763.15 | protein_coding | MMACHC | No | No | 25974 | A0A0C4DGU2 Q9Y4U1 |
| TVIS10013136 | HBV | ENSG00000132763.15 | protein_coding | MMACHC | No | No | 25974 | A0A0C4DGU2 Q9Y4U1 |
| TVIS30023578 | HIV | ENSG00000132763.15 | protein_coding | MMACHC | No | No | 25974 | A0A0C4DGU2 Q9Y4U1 |
| TVIS20019949 | HPV | ENSG00000132763.15 | protein_coding | MMACHC | No | No | 25974 | A0A0C4DGU2 Q9Y4U1 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | MMACHC |
|---|---|
| DrugBank ID | DB00200 |
| Drug Name | Hydroxocobalamin |
| Target ID | BE0002175 |
| UniProt ID | Q9Y4U1 |
| Regulation Type | other/unknown |
| PubMed IDs | 17139284; 17016423; 16311595 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Lerner-Ellis JP, Tirone JC, Pawelek PD, Dore C, Atkinson JL, Watkins D, Morel CF, Fujiwara TM, Moras E, Hosack AR, Dunbar GV, Antonicka H, Forgetta V, Dobson CM, Leclerc D, Gravel RA, Shoubridge EA, Coulton JW, Lepage P, Rommens JM, Morgan K, Rosenblatt DS: Identification of the gene responsible for methylmalonic aciduria and homocystinuria, cblC type. Nat Genet. 2006 Jan;38(1):93-100. Epub 2005 Nov 27. |
| Groups | Approved |
| Direct Classification | Cobalamin derivatives |
| SMILES | [N+]1=2[Co-3]345([N+]6=C7[C@H]([C@@](CC(=O)N)(C)[C@@]6([C@@]6(N3C(=C(C)C3=[N+]4C(C(C)(C)[C@@H]3CCC(=O)N)=CC3=[N+]5C(=C7C)[C@@](CC(=O)N)([C@@H]3CCC(=O)N)C)[C@@](C)([C@H]6CC(=O)N)CCC(NC[C@@H](C)OP(=O)(O[C@@H]3[C@H](O[C@H](N(C4=CC(=C(C=C14)C)C)C=2)[C@@H]3O)CO)[O-])=O)[H])C)CCC(=O)N)O[H] |
| Pathways | |
| PharmGKB | PA164768689 |
| ChEMBL | CHEMBL2103737 |
