| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10010538 | HBV | ENSG00000132763.15 | protein_coding | MMACHC | No | No | 25974 | A0A0C4DGU2 Q9Y4U1 |
| TVIS10009818 | HBV | ENSG00000132763.15 | protein_coding | MMACHC | No | No | 25974 | A0A0C4DGU2 Q9Y4U1 |
| TVIS10010539 | HBV | ENSG00000132763.15 | protein_coding | MMACHC | No | No | 25974 | A0A0C4DGU2 Q9Y4U1 |
| TVIS10013136 | HBV | ENSG00000132763.15 | protein_coding | MMACHC | No | No | 25974 | A0A0C4DGU2 Q9Y4U1 |
| TVIS30023578 | HIV | ENSG00000132763.15 | protein_coding | MMACHC | No | No | 25974 | A0A0C4DGU2 Q9Y4U1 |
| TVIS20019949 | HPV | ENSG00000132763.15 | protein_coding | MMACHC | No | No | 25974 | A0A0C4DGU2 Q9Y4U1 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | MMACHC |
|---|---|
| DrugBank ID | DB00115 |
| Drug Name | Cyanocobalamin |
| Target ID | BE0002175 |
| UniProt ID | Q9Y4U1 |
| Regulation Type | cofactor |
| PubMed IDs | 16843692; 17431913; 16714133; 16311595; 25820384 |
| Citations | Chandler RJ, Aswani V, Tsai MS, Falk M, Wehrli N, Stabler S, Allen R, Sedensky M, Kazazian HH, Venditti CP: Propionyl-CoA and adenosylcobalamin metabolism in Caenorhabditis elegans: evidence for a role of methylmalonyl-CoA epimerase in intermediary metabolism. Mol Genet Metab. 2006 Sep-Oct;89(1-2):64-73. Epub 2006 Jul 14.@@Ben-Omran TI, Wong H, Blaser S, Feigenbaum A: Late-onset cobalamin-C disorder: a challenging diagnosis. Am J Med Genet A. 2007 May 1;143A(9):979-84.@@Morel CF, Lerner-Ellis JP, Rosenblatt DS: Combined methylmalonic aciduria and homocystinuria (cblC): phenotype-genotype correlations and ethnic-specific observations. Mol Genet Metab. 2006 Aug;88(4):315-21. Epub 2006 May 22.@@Lerner-Ellis JP, Tirone JC, Pawelek PD, Dore C, Atkinson JL, Watkins D, Morel CF, Fujiwara TM, Moras E, Hosack AR, Dunbar GV, Antonicka H, Forgetta V, Dobson CM, Leclerc D, Gravel RA, Shoubridge EA, Coulton JW, Lepage P, Rommens JM, Morgan K, Rosenblatt DS: Identification of the gene responsible for methylmalonic aciduria and homocystinuria, cblC type. Nat Genet. 2006 Jan;38(1):93-100. Epub 2005 Nov 27.@@Obeid R, Fedosov SN, Nexo E: Cobalamin coenzyme forms are not likely to be superior to cyano- and hydroxyl-cobalamin in prevention or treatment of cobalamin deficiency. Mol Nutr Food Res. 2015 Jul;59(7):1364-72. doi: 10.1002/mnfr.201500019. Epub 2015 May 12. |
| Groups | Approved; Nutraceutical |
| Direct Classification | Cobalamin derivatives |
| SMILES | C[C@H](CNC(=O)CC[C@]1(C)[C@@H](CC(N)=O)[C@H]2N=C1C(C)=C1/N=C(/C=C3N=C(C(C)=C4[C@@H](CCC(N)=O)[C@](C)(CC(N)=O)[C@@]2(C)N4[Co+]C#N)[C@@](C)(CC(N)=O)[C@@H]3CCC(N)=O)C(C)(C)[C@@H]1CCC(N)=O)OP([O-])(=O)O[C@@H]1[C@@H](CO)O[C@@H]([C@@H]1O)N1C=NC2=C1C=C(C)C(C)=C2 |
| Pathways | |
| PharmGKB | PA451892 |
| ChEMBL | CHEMBL2110563 |
