| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10004594 | HBV | ENSG00000175591.12 | protein_coding | P2RY2 | No | No | 5029 | P41231 |
| TVIS10026652 | HBV | ENSG00000175591.12 | protein_coding | P2RY2 | No | No | 5029 | P41231 |
| TVIS10052252 | HBV | ENSG00000175591.12 | protein_coding | P2RY2 | No | No | 5029 | P41231 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | P2RY2 |
|---|---|
| DrugBank ID | DB04983 |
| Drug Name | Denufosol |
| Target ID | BE0002401 |
| UniProt ID | P41231 |
| Regulation Type | |
| PubMed IDs | 12407168; 12407169; 12458155; 14507899; 15704203; 16475938; 17446337 |
| Citations | Maminishkis A, Jalickee S, Blaug SA, Rymer J, Yerxa BR, Peterson WM, Miller SS: The P2Y(2) receptor agonist INS37217 stimulates RPE fluid transport in vitro and retinal reattachment in rat. Invest Ophthalmol Vis Sci. 2002 Nov;43(11):3555-66.@@Meyer CH, Hotta K, Peterson WM, Toth CA, Jaffe GJ: Effect of INS37217, a P2Y(2) receptor agonist, on experimental retinal detachment and electroretinogram in adult rabbits. Invest Ophthalmol Vis Sci. 2002 Nov;43(11):3567-74.@@Kellerman D, Evans R, Mathews D, Shaffer C: Inhaled P2Y2 receptor agonists as a treatment for patients with Cystic Fibrosis lung disease. Adv Drug Deliv Rev. 2002 Dec 5;54(11):1463-74.@@Nour M, Quiambao AB, Peterson WM, Al-Ubaidi MR, Naash MI: P2Y(2) receptor agonist INS37217 enhances functional recovery after detachment caused by subretinal injection in normal and rds mice. Invest Ophthalmol Vis Sci. 2003 Oct;44(10):4505-14.@@Deterding R, Retsch-Bogart G, Milgram L, Gibson R, Daines C, Zeitlin PL, Milla C, Marshall B, Lavange L, Engels J, Mathews D, Gorden J, Schaberg A, Williams J, Ramsey B: Safety and tolerability of denufosol tetrasodium inhalation solution, a novel P2Y2 receptor agonist: results of a phase 1/phase 2 multicenter study in mild to moderate cystic fibrosis. Pediatr Pulmonol. 2005 Apr;39(4):339-48.@@Brunschweiger A, Muller CE: P2 receptors activated by uracil nucleotides--an update. Curr Med Chem. 2006;13(3):289-312.@@Deterding RR, Lavange LM, Engels JM, Mathews DW, Coquillette SJ, Brody AS, Millard SP, Ramsey BW: Phase 2 randomized safety and efficacy trial of nebulized denufosol tetrasodium in cystic fibrosis. Am J Respir Crit Care Med. 2007 Aug 15;176(4):362-9. Epub 2007 Apr 19. |
| Groups | Investigational |
| Direct Classification | (5'->5')-dinucleotides |
| SMILES | [H]N([H])C1=NC(=O)N(C=C1)[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=CC(=O)N([H])C2=O)O1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL507282 |
