| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10017304 | HBV | ENSG00000160209.19 | protein_coding | PDXK | No | No | 8566 | F2Z2Y4 O00764 |
| TVIS30054773 | HIV | ENSG00000160209.19 | protein_coding | PDXK | No | No | 8566 | F2Z2Y4 O00764 |
| TVIS20002225 | HPV | ENSG00000160209.19 | protein_coding | PDXK | No | No | 8566 | F2Z2Y4 O00764 |
| TVIS20068127 | HPV | ENSG00000160209.19 | protein_coding | PDXK | No | No | 8566 | F2Z2Y4 O00764 |
| TVIS20045247 | HPV | ENSG00000160209.19 | protein_coding | PDXK | No | No | 8566 | F2Z2Y4 O00764 |
| TVIS44042877 | HTLV-1 | ENSG00000160209.19 | protein_coding | PDXK | No | No | 8566 | F2Z2Y4 O00764 |
| TVIS44042961 | HTLV-1 | ENSG00000160209.19 | protein_coding | PDXK | No | No | 8566 | F2Z2Y4 O00764 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PDXK |
|---|---|
| DrugBank ID | DB00165 |
| Drug Name | Pyridoxine |
| Target ID | BE0000042 |
| UniProt ID | O00764 |
| Regulation Type | ligand |
| PubMed IDs | 16494569; 16978644; 16466641; 18256491; 17766369 |
| Citations | Adams JB, George F, Audhya T: Abnormally high plasma levels of vitamin B6 in children with autism not taking supplements compared to controls not taking supplements. J Altern Complement Med. 2006 Jan-Feb;12(1):59-63.@@Newman JA, Das SK, Sedelnikova SE, Rice DW: The crystal structure of an ADP complex of Bacillus subtilis pyridoxal kinase provides evidence for the parallel emergence of enzyme activity during evolution. J Mol Biol. 2006 Oct 20;363(2):520-30. Epub 2006 Aug 12.@@Kim SY, An JJ, Kim DW, Choi SH, Lee SH, Hwang SI, Kwon OS, Kang TC, Won MH, Cho SW, Park J, Eum WS, Lee KS, Choi SY: Tat-mediated protein transduction of human brain pyridoxine-5-P oxidase into PC12 cells. J Biochem Mol Biol. 2006 Jan 31;39(1):76-83.@@Nagahashi Y, Tazoe M, Hoshino T: Cloning of the pyridoxine 5'-phosphate phosphatase gene (pdxP) and vitamin B6 production in pdxP recombinant Sinorhizobium meliloti. Biosci Biotechnol Biochem. 2008 Feb;72(2):421-7. Epub 2008 Feb 7.@@Musayev FN, di Salvo ML, Ko TP, Gandhi AK, Goswami A, Schirch V, Safo MK: Crystal Structure of human pyridoxal kinase: structural basis of M(+) and M(2+) activation. Protein Sci. 2007 Oct;16(10):2184-94. doi: 10.1110/ps.073022107. Epub 2007 Aug 31. |
| Groups | Approved; Investigational; Nutraceutical; Vet_approved |
| Direct Classification | Pyridoxines |
| SMILES | CC1=C(O)C(CO)=C(CO)C=N1 |
| Pathways | Hypophosphatasia; Vitamin B6 Metabolism |
| PharmGKB | PA451897 |
| ChEMBL | CHEMBL1364 |
