| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30079096 | HIV | ENSG00000180739.15 | protein_coding | S1PR5 | No | No | 53637 | Q9H228 |
| TVIS20020750 | HPV | ENSG00000180739.15 | protein_coding | S1PR5 | No | No | 53637 | Q9H228 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | S1PR5 |
|---|---|
| DrugBank ID | DB12371 |
| Drug Name | Siponimod |
| Target ID | BE0002432 |
| UniProt ID | Q9H228 |
| Regulation Type | modulator |
| PubMed IDs | 29138536; 29735753; 26856814 |
| Citations | Gajofatto A: Spotlight on siponimod and its potential in the treatment of secondary progressive multiple sclerosis: the evidence to date. Drug Des Devel Ther. 2017 Nov 2;11:3153-3157. doi: 10.2147/DDDT.S122249. eCollection 2017.@@Glaenzel U, Jin Y, Nufer R, Li W, Schroer K, Adam-Stitah S, Peter van Marle S, Legangneux E, Borell H, James AD, Meissner A, Camenisch G, Gardin A: Metabolism and Disposition of Siponimod, a Novel Selective S1P1/S1P5 Agonist, in Healthy Volunteers and In Vitro Identification of Human Cytochrome P450 Enzymes Involved in Its Oxidative Metabolism. Drug Metab Dispos. 2018 Jul;46(7):1001-1013. doi: 10.1124/dmd.117.079574. Epub 2018 May 7.@@O'Sullivan C, Schubart A, Mir AK, Dev KK: The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures. J Neuroinflammation. 2016 Feb 8;13:31. doi: 10.1186/s12974-016-0494-x. |
| Groups | Approved; Investigational |
| Direct Classification | Trifluoromethylbenzenes |
| SMILES | CCC1=CC(=CC=C1CN1CC(C1)C(O)=O)C(C)=NOCC1=CC=C(C2CCCCC2)C(=C1)C(F)(F)F |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL2336071 |
