| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10037580 | HBV | ENSG00000168447.11 | protein_coding | SCNN1B | No | No | 6338 | B2R812 P51168 |
| TVIS30040586 | HIV | ENSG00000168447.11 | protein_coding | SCNN1B | No | No | 6338 | B2R812 P51168 |
| TVIS20043413 | HPV | ENSG00000168447.11 | protein_coding | SCNN1B | No | No | 6338 | B2R812 P51168 |
| TVIS20041991 | HPV | ENSG00000168447.11 | protein_coding | SCNN1B | No | No | 6338 | B2R812 P51168 |
| TVIS20020651 | HPV | ENSG00000168447.11 | protein_coding | SCNN1B | No | No | 6338 | B2R812 P51168 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SCNN1B |
|---|---|
| DrugBank ID | DB00594 |
| Drug Name | Amiloride |
| Target ID | BE0000024 |
| UniProt ID | P51168 |
| Regulation Type | inhibitor |
| PubMed IDs | 12746257; 15681398; 12396248; 11882592; 15198480 |
| Citations | Lebowitz J, An B, Edinger RS, Zeidel ML, Johnson JP: Effect of altered Na+ entry on expression of apical and basolateral transport proteins in A6 epithelia. Am J Physiol Renal Physiol. 2003 Sep;285(3):F524-31. Epub 2003 May 13.@@Planes C, Leyvraz C, Uchida T, Angelova MA, Vuagniaux G, Hummler E, Matthay M, Clerici C, Rossier B: In vitro and in vivo regulation of transepithelial lung alveolar sodium transport by serine proteases. Am J Physiol Lung Cell Mol Physiol. 2005 Jun;288(6):L1099-109. Epub 2005 Jan 28.@@Yamagata T, Yamagata Y, Nishimoto T, Nakanishi M, Nakanishi H, Minakata Y, Mune M, Yukawa S: The impact of phorbol ester on the regulation of amiloride-sensitive epithelial sodium channel in alveolar type ii epithelial cells. Exp Lung Res. 2002 Oct-Nov;28(7):543-62.@@Brooks HL, Allred AJ, Beutler KT, Coffman TM, Knepper MA: Targeted proteomic profiling of renal Na(+) transporter and channel abundances in angiotensin II type 1a receptor knockout mice. Hypertension. 2002 Feb;39(2 Pt 2):470-3.@@Kamide K, Tanaka C, Takiuchi S, Miwa Y, Yoshii M, Horio T, Kawano Y, Miyata T: Six missense mutations of the epithelial sodium channel beta and gamma subunits in Japanese hypertensives. Hypertens Res. 2004 May;27(5):333-8. |
| Groups | Approved |
| Direct Classification | Aminopyrazines |
| SMILES | NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N |
| Pathways | Amiloride Action Pathway |
| PharmGKB | PA448368 |
| ChEMBL | CHEMBL945 |
