| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30079080 | HIV | ENSG00000169836.5 | protein_coding | TACR3 | No | No | 6870 | P29371 |
| TVIS30060720 | HIV | ENSG00000169836.5 | protein_coding | TACR3 | No | No | 6870 | P29371 |
| TVIS20033534 | HPV | ENSG00000169836.5 | protein_coding | TACR3 | No | No | 6870 | P29371 |
| TVIS20058844 | HPV | ENSG00000169836.5 | protein_coding | TACR3 | No | No | 6870 | P29371 |
| TVIS20057902 | HPV | ENSG00000169836.5 | protein_coding | TACR3 | No | No | 6870 | P29371 |
| TVIS44008558 | HTLV-1 | ENSG00000169836.5 | protein_coding | TACR3 | No | No | 6870 | P29371 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | TACR3 |
|---|---|
| DrugBank ID | DB06429 |
| Drug Name | Talnetant |
| Target ID | BE0002371 |
| UniProt ID | P29371 |
| Regulation Type | antagonist |
| PubMed IDs | 17172464; 17728699; 9190866 |
| Citations | Tian G, Wilkins D, Scott CW: Neurokinin-3 receptor-specific antagonists talnetant and osanetant show distinct mode of action in cellular Ca2+ mobilization but display similar binding kinetics and identical mechanism of binding in ligand cross-competition. Mol Pharmacol. 2007 Mar;71(3):902-11. Epub 2006 Dec 15.@@Dawson LA, Cato KJ, Scott C, Watson JM, Wood MD, Foxton R, de la Flor R, Jones GA, Kew JN, Cluderay JE, Southam E, Murkitt GS, Gartlon J, Pemberton DJ, Jones DN, Davies CH, Hagan J: In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant): potential therapeutic utility in the treatment of schizophrenia. Neuropsychopharmacology. 2008 Jun;33(7):1642-52. Epub 2007 Aug 29.@@Sarau HM, Griswold DE, Potts W, Foley JJ, Schmidt DB, Webb EF, Martin LD, Brawner ME, Elshourbagy NA, Medhurst AD, Giardina GA, Hay DW: Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist. J Pharmacol Exp Ther. 1997 Jun;281(3):1303-11. |
| Groups | Investigational |
| Direct Classification | Phenylquinolines |
| SMILES | CCC(NC(=O)C1=C(O)C(=NC2=CC=CC=C12)C1=CC=CC=C1)C1=CC=CC=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL275544 |
