| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10013564 | HBV | ENSG00000151090.20 | protein_coding | THRB | No | No | 7068 | P10828 |
| TVIS10013565 | HBV | ENSG00000151090.20 | protein_coding | THRB | No | No | 7068 | P10828 |
| TVIS10019904 | HBV | ENSG00000151090.20 | protein_coding | THRB | No | No | 7068 | P10828 |
| TVIS10004801 | HBV | ENSG00000151090.20 | protein_coding | THRB | No | No | 7068 | P10828 |
| TVIS10018385 | HBV | ENSG00000151090.20 | protein_coding | THRB | No | No | 7068 | P10828 |
| TVIS10006591 | HBV | ENSG00000151090.20 | protein_coding | THRB | No | No | 7068 | P10828 |
| TVIS10004802 | HBV | ENSG00000151090.20 | protein_coding | THRB | No | No | 7068 | P10828 |
| TVIS10014866 | HBV | ENSG00000151090.20 | protein_coding | THRB | No | No | 7068 | P10828 |
| TVIS10014678 | HBV | ENSG00000151090.20 | protein_coding | THRB | No | No | 7068 | P10828 |
| TVIS10004803 | HBV | ENSG00000151090.20 | protein_coding | THRB | No | No | 7068 | P10828 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | THRB |
|---|---|
| DrugBank ID | DB00451 |
| Drug Name | Levothyroxine |
| Target ID | BE0000315 |
| UniProt ID | P10828 |
| Regulation Type | agonist |
| PubMed IDs | 17016423; 18816177; 20151830; 16053391; 20051527 |
| Citations | Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Marazuela M, Nattero L, Moure D, Garcia-Polo I, Figueroa-Vega N, Guijarro C: Thyroid hormone resistance and pituitary enlargement after thyroid ablation in a woman on levothyroxine treatment. Thyroid. 2008 Oct;18(10):1119-23. doi: 10.1089/thy.2007.0375.@@Sivakumar T, Chaidarun S: Resistance to thyroid hormone in a patient with coexisting Graves' disease. Thyroid. 2010 Feb;20(2):213-6. doi: 10.1089/thy.2009.0175.@@Grasberger H, Ringkananont U, Croxson M, Refetoff S: Resistance to thyroid hormone in a patient with thyroid dysgenesis. Thyroid. 2005 Jul;15(7):730-3.@@Cheng SY, Leonard JL, Davis PJ: Molecular aspects of thyroid hormone actions. Endocr Rev. 2010 Apr;31(2):139-70. doi: 10.1210/er.2009-0007. Epub 2010 Jan 5. |
| Groups | Approved |
| Direct Classification | Phenylalanine and derivatives |
| SMILES | N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C(O)=O |
| Pathways | Thyroid Hormone Synthesis |
| PharmGKB | PA450221 |
| ChEMBL | CHEMBL1624 |
