| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30014306 | HIV | ENSG00000198900.7 | protein_coding | TOP1 | Yes | No | 7150 | P11387 |
| TVIS30014330 | HIV | ENSG00000198900.7 | protein_coding | TOP1 | Yes | No | 7150 | P11387 |
| TVIS30010713 | HIV | ENSG00000198900.7 | protein_coding | TOP1 | Yes | No | 7150 | P11387 |
| TVIS30007991 | HIV | ENSG00000198900.7 | protein_coding | TOP1 | Yes | No | 7150 | P11387 |
| TVIS30010714 | HIV | ENSG00000198900.7 | protein_coding | TOP1 | Yes | No | 7150 | P11387 |
| TVIS30007992 | HIV | ENSG00000198900.7 | protein_coding | TOP1 | Yes | No | 7150 | P11387 |
| TVIS30015925 | HIV | ENSG00000198900.7 | protein_coding | TOP1 | Yes | No | 7150 | P11387 |
| TVIS30015924 | HIV | ENSG00000198900.7 | protein_coding | TOP1 | Yes | No | 7150 | P11387 |
| TVIS30012871 | HIV | ENSG00000198900.7 | protein_coding | TOP1 | Yes | No | 7150 | P11387 |
| TVIS30012872 | HIV | ENSG00000198900.7 | protein_coding | TOP1 | Yes | No | 7150 | P11387 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | TOP1 |
|---|---|
| DrugBank ID | DB00970 |
| Drug Name | Dactinomycin |
| Target ID | BE0000971 |
| UniProt ID | P11387 |
| Regulation Type | inhibitor |
| PubMed IDs | 9917336 |
| Citations | Alkorta I, Park C, Kong J, Garbisu C, Alberti M, Pon N, Hearst JE: Rhodobacter capsulatus DNA topoisomerase I purification and characterization. Arch Biochem Biophys. 1999 Feb 1;362(1):123-30. doi: 10.1006/abbi.1998.1023. |
| Groups | Approved; Investigational |
| Direct Classification | Cyclic depsipeptides |
| SMILES | [H][C@@]12CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)C1=C3N=C4C(OC3=C(C)C=C1)=C(C)C(=O)C(N)=C4C(=O)N[C@H]1[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@]3([H])CCCN3C(=O)[C@H](NC1=O)C(C)C)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C2=O)C(C)C |
| Pathways | |
| PharmGKB | PA151917012 |
| ChEMBL | CHEMBL1554 |
