| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30001788 | HIV | ENSG00000148680.16 | protein_coding | HTR7 | No | No | 3363 | P34969 |
| TVIS30081632 | HIV | ENSG00000148680.16 | protein_coding | HTR7 | No | No | 3363 | P34969 |
| TVIS20006328 | HPV | ENSG00000148680.16 | protein_coding | HTR7 | No | No | 3363 | P34969 |
| TVIS20033320 | HPV | ENSG00000148680.16 | protein_coding | HTR7 | No | No | 3363 | P34969 |
| TVIS20048781 | HPV | ENSG00000148680.16 | protein_coding | HTR7 | No | No | 3363 | P34969 |
| TVIS20036895 | HPV | ENSG00000148680.16 | protein_coding | HTR7 | No | No | 3363 | P34969 |
| TVIS20041222 | HPV | ENSG00000148680.16 | protein_coding | HTR7 | No | No | 3363 | P34969 |
| TVIS44004709 | HTLV-1 | ENSG00000148680.16 | protein_coding | HTR7 | No | No | 3363 | P34969 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | HTR7 |
|---|---|
| DrugBank ID | DB01267 |
| Drug Name | Paliperidone |
| Target ID | BE0000650 |
| UniProt ID | P34969 |
| Regulation Type | |
| PubMed IDs | 18996971; 19509219; 20827463 |
| Citations | Knight JA, Smith C, Toohey N, Klein MT, Teitler M: Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists. Mol Pharmacol. 2009 Feb;75(2):374-80. doi: 10.1124/mol.108.052084. Epub 2008 Nov 7.@@Toohey N, Klein MT, Knight J, Smith C, Teitler M: Human 5-HT7 receptor-induced inactivation of forskolin-stimulated adenylate cyclase by risperidone, 9-OH-risperidone and other "inactivating antagonists". Mol Pharmacol. 2009 Sep;76(3):552-9. doi: 10.1124/mol.109.056283. Epub 2009 Jun 9.@@Teitler M, Toohey N, Knight JA, Klein MT, Smith C: Clozapine and other competitive antagonists reactivate risperidone-inactivated h5-HT7 receptors: radioligand binding and functional evidence for GPCR homodimer protomer interactions. Psychopharmacology (Berl). 2010 Dec;212(4):687-97. doi: 10.1007/s00213-010-2001-x. Epub 2010 Sep 9. |
| Groups | Approved |
| Direct Classification | Pyridopyrimidines |
| SMILES | CC1=C(CCN2CCC(CC2)C2=NOC3=C2C=CC(F)=C3)C(=O)N2CCCC(O)C2=N1 |
| Pathways | |
| PharmGKB | PA163518919 |
| ChEMBL | CHEMBL1621 |
