| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30072183 | HIV | ENSG00000097007.20 | protein_coding | ABL1 | Yes | No | 25 | P00519 |
| TVIS30072184 | HIV | ENSG00000097007.20 | protein_coding | ABL1 | Yes | No | 25 | P00519 |
| TVIS30020995 | HIV | ENSG00000097007.20 | protein_coding | ABL1 | Yes | No | 25 | P00519 |
| TVIS30072185 | HIV | ENSG00000097007.20 | protein_coding | ABL1 | Yes | No | 25 | P00519 |
| TVIS30072186 | HIV | ENSG00000097007.20 | protein_coding | ABL1 | Yes | No | 25 | P00519 |
| TVIS30072187 | HIV | ENSG00000097007.20 | protein_coding | ABL1 | Yes | No | 25 | P00519 |
| TVIS30072188 | HIV | ENSG00000097007.20 | protein_coding | ABL1 | Yes | No | 25 | P00519 |
| TVIS30072189 | HIV | ENSG00000097007.20 | protein_coding | ABL1 | Yes | No | 25 | P00519 |
| TVIS30072190 | HIV | ENSG00000097007.20 | protein_coding | ABL1 | Yes | No | 25 | P00519 |
| TVIS44050717 | HTLV-1 | ENSG00000097007.20 | protein_coding | ABL1 | Yes | No | 25 | P00519 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ABL1 |
|---|---|
| DrugBank ID | DB01254 |
| Drug Name | Dasatinib |
| Target ID | BE0000014 |
| UniProt ID | P00519 |
| Regulation Type | inhibitor |
| PubMed IDs | 17701954; 17154512; 16775234 |
| Citations | Piccaluga PP, Paolini S, Martinelli G: Tyrosine kinase inhibitors for the treatment of Philadelphia chromosome-positive adult acute lymphoblastic leukemia. Cancer. 2007 Sep 15;110(6):1178-86.@@Das J, Chen P, Norris D, Padmanabha R, Lin J, Moquin RV, Shen Z, Cook LS, Doweyko AM, Pitt S, Pang S, Shen DR, Fang Q, de Fex HF, McIntyre KW, Shuster DJ, Gillooly KM, Behnia K, Schieven GL, Wityak J, Barrish JC: 2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor. J Med Chem. 2006 Nov 16;49(23):6819-32.@@Talpaz M, Shah NP, Kantarjian H, Donato N, Nicoll J, Paquette R, Cortes J, O'Brien S, Nicaise C, Bleickardt E, Blackwood-Chirchir MA, Iyer V, Chen TT, Huang F, Decillis AP, Sawyers CL: Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med. 2006 Jun 15;354(24):2531-41. |
| Groups | Approved; Investigational |
| Direct Classification | Aromatic anilides |
| SMILES | CC1=NC(NC2=NC=C(S2)C(=O)NC2=C(C)C=CC=C2Cl)=CC(=N1)N1CCN(CCO)CC1 |
| Pathways | Dasatinib Inhibition of BCR-ABL |
| PharmGKB | PA162372878 |
| ChEMBL | CHEMBL1421 |
