| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20066966 | HPV | ENSG00000165092.13 | protein_coding | ALDH1A1 | No | No | 216 | P00352 |
| TVIS20020756 | HPV | ENSG00000165092.13 | protein_coding | ALDH1A1 | No | No | 216 | P00352 |
| TVIS20020573 | HPV | ENSG00000165092.13 | protein_coding | ALDH1A1 | No | No | 216 | P00352 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ALDH1A1 |
|---|---|
| DrugBank ID | DB00755 |
| Drug Name | Tretinoin |
| Target ID | BE0000554 |
| UniProt ID | P00352 |
| Regulation Type | substrate |
| PubMed IDs | 15366004; 15245423; 16837774; 16207763; 16166285 |
| Citations | Mic FA, Molotkov A, Molotkova N, Duester G: Raldh2 expression in optic vesicle generates a retinoic acid signal needed for invagination of retina during optic cup formation. Dev Dyn. 2004 Oct;231(2):270-7.@@Everts HB, King LE Jr, Sundberg JP, Ong DE: Hair cycle-specific immunolocalization of retinoic acid synthesizing enzymes Aldh1a2 and Aldh1a3 indicate complex regulation. J Invest Dermatol. 2004 Aug;123(2):258-63.@@Gidlof AC, Ocaya P, Olofsson PS, Torma H, Sirsjo A: Differences in retinol metabolism and proliferative response between neointimal and medial smooth muscle cells. J Vasc Res. 2006;43(4):392-8. Epub 2006 Jul 6.@@Matt N, Dupe V, Garnier JM, Dennefeld C, Chambon P, Mark M, Ghyselinck NB: Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells. Development. 2005 Nov;132(21):4789-800. Epub 2005 Oct 5.@@Kim H, Lapointe J, Kaygusuz G, Ong DE, Li C, van de Rijn M, Brooks JD, Pollack JR: The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancer. Cancer Res. 2005 Sep 15;65(18):8118-24. |
| Groups | Approved; Investigational; Nutraceutical |
| Direct Classification | |
| SMILES | CC(C=CC1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O |
| Pathways | Retinol Metabolism; Vitamin A Deficiency |
| PharmGKB | PA164746900 |
| ChEMBL | CHEMBL38 |
