| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10018487 | HBV | ENSG00000166598.16 | protein_coding | HSP90B1 | No | No | 7184 | P14625 |
| TVIS30033897 | HIV | ENSG00000166598.16 | protein_coding | HSP90B1 | No | No | 7184 | P14625 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | HSP90B1 |
|---|---|
| DrugBank ID | DB02424 |
| Drug Name | Geldanamycin |
| Target ID | BE0001165 |
| UniProt ID | P14625 |
| Regulation Type | inhibitor |
| PubMed IDs | 9295332; 12729599 |
| Citations | Grenert JP, Sullivan WP, Fadden P, Haystead TA, Clark J, Mimnaugh E, Krutzsch H, Ochel HJ, Schulte TW, Sausville E, Neckers LM, Toft DO: The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation. J Biol Chem. 1997 Sep 19;272(38):23843-50.@@Carreras CW, Schirmer A, Zhong Z, Santi DV: Filter binding assay for the geldanamycin-heat shock protein 90 interaction. Anal Biochem. 2003 Jun 1;317(1):40-6. |
| Groups | Experimental; Investigational |
| Direct Classification | Macrolactams |
| SMILES | CO[C@H]1C[C@H](C)CC2=C(OC)C(=O)C=C(NC(=O)C(C)=CC=C/[C@H](OC)[C@@H](OC(N)=O)C(C)=C[C@H](C)[C@H]1O)C2=O |
| Pathways | |
| PharmGKB | PA152031327 |
| ChEMBL | CHEMBL278315 |
