| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10018487 | HBV | ENSG00000166598.16 | protein_coding | HSP90B1 | No | No | 7184 | P14625 |
| TVIS30033897 | HIV | ENSG00000166598.16 | protein_coding | HSP90B1 | No | No | 7184 | P14625 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | HSP90B1 |
|---|---|
| DrugBank ID | DB00615 |
| Drug Name | Rifabutin |
| Target ID | BE0001165 |
| UniProt ID | P14625 |
| Regulation Type | other/unknown |
| PubMed IDs | 14660597; 8617772; 9428803 |
| Citations | Barzilay E, Ben-Califa N, Supino-Rosin L, Kashman Y, Hirschberg K, Elazar Z, Neumann D: Geldanamycin-associated inhibition of intracellular trafficking is attributed to a co-purified activity. J Biol Chem. 2004 Feb 20;279(8):6847-52. Epub 2003 Dec 1.@@Chavany C, Mimnaugh E, Miller P, Bitton R, Nguyen P, Trepel J, Whitesell L, Schnur R, Moyer J, Neckers L: p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2. J Biol Chem. 1996 Mar 1;271(9):4974-7.@@Lawson B, Brewer JW, Hendershot LM: Geldanamycin, an hsp90/GRP94-binding drug, induces increased transcription of endoplasmic reticulum (ER) chaperones via the ER stress pathway. J Cell Physiol. 1998 Feb;174(2):170-8. |
| Groups | Approved; Investigational |
| Direct Classification | Macrolactams |
| SMILES | CO[C@H]1C=CO[C@@]2(C)OC3=C(C2=O)C2=C(C(O)=C3C)C(=O)C(NC(=O)C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)=C1NC3(CCN(CC3)CC(C)C)N=C21 |
| Pathways | |
| PharmGKB | PA451249 |
| ChEMBL | CHEMBL444633 |
