| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10025373 | HBV | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
| TVIS30009912 | HIV | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
| TVIS30074430 | HIV | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
| TVIS30072877 | HIV | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
| TVIS30072878 | HIV | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
| TVIS20028048 | HPV | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
| TVIS20069516 | HPV | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
| TVIS20028052 | HPV | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
| TVIS20069517 | HPV | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
| TVIS20028065 | HPV | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | POLA1 |
|---|---|
| DrugBank ID | DB01073 |
| Drug Name | Fludarabine |
| Target ID | BE0000546 |
| UniProt ID | P09884 |
| Regulation Type | inhibitor |
| PubMed IDs | 17139284; 17016423; 19519505; 19325518; 17168705 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Lech-Maranda E, Korycka A, Robak T: Clofarabine as a novel nucleoside analogue approved to treat patients with haematological malignancies: mechanism of action and clinical activity. Mini Rev Med Chem. 2009 Jun;9(7):805-12.@@Robak T, Korycka A, Lech-Maranda E, Robak P: Current status of older and new purine nucleoside analogues in the treatment of lymphoproliferative diseases. Molecules. 2009 Mar 23;14(3):1183-226. doi: 10.3390/molecules14031183.@@Robak T, Lech-Maranda E, Korycka A, Robak E: Purine nucleoside analogs as immunosuppressive and antineoplastic agents: mechanism of action and clinical activity. Curr Med Chem. 2006;13(26):3165-89. |
| Groups | Approved |
| Direct Classification | Purine nucleosides |
| SMILES | NC1=NC(F)=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O |
| Pathways | |
| PharmGKB | PA449655 |
| ChEMBL | CHEMBL1568 |
