| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30053672 | HIV | ENSG00000198900.7 | protein_coding | TOP1 | Yes | No | 7150 | P11387 |
| TVIS20018930 | HPV | ENSG00000198900.7 | protein_coding | TOP1 | Yes | No | 7150 | P11387 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | TOP1 |
|---|---|
| DrugBank ID | DB00997 |
| Drug Name | Doxorubicin |
| Target ID | BE0000971 |
| UniProt ID | P11387 |
| Regulation Type | inhibitor |
| PubMed IDs | 30391699 |
| Citations | Khalil OM, Gedawy EM, El-Malah AA, Adly ME: Novel nalidixic acid derivatives targeting topoisomerase II enzyme; Design, synthesis, anticancer activity and effect on cell cycle profile. Bioorg Chem. 2019 Mar;83:262-276. doi: 10.1016/j.bioorg.2018.10.058. Epub 2018 Oct 30. |
| Groups | Approved; Investigational |
| Direct Classification | Anthracyclines |
| SMILES | COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C(=O)CO)C(O)=C1C2=O |
| Pathways | Doxorubicin Metabolism Pathway |
| PharmGKB | PA449412 |
| ChEMBL | CHEMBL53463 |
