| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10040912 | HBV | ENSG00000077097.17 | protein_coding | TOP2B | No | No | 7155 | Q02880 |
| TVIS30003476 | HIV | ENSG00000077097.17 | protein_coding | TOP2B | No | No | 7155 | Q02880 |
| TVIS30008273 | HIV | ENSG00000077097.17 | protein_coding | TOP2B | No | No | 7155 | Q02880 |
| TVIS30056472 | HIV | ENSG00000077097.17 | protein_coding | TOP2B | No | No | 7155 | Q02880 |
| TVIS30056473 | HIV | ENSG00000077097.17 | protein_coding | TOP2B | No | No | 7155 | Q02880 |
| TVIS30056474 | HIV | ENSG00000077097.17 | protein_coding | TOP2B | No | No | 7155 | Q02880 |
| TVIS30056475 | HIV | ENSG00000077097.17 | protein_coding | TOP2B | No | No | 7155 | Q02880 |
| TVIS20032084 | HPV | ENSG00000077097.17 | protein_coding | TOP2B | No | No | 7155 | Q02880 |
| TVIS20036520 | HPV | ENSG00000077097.17 | protein_coding | TOP2B | No | No | 7155 | Q02880 |
| TVIS44008532 | HTLV-1 | ENSG00000077097.17 | protein_coding | TOP2B | No | No | 7155 | Q02880 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | TOP2B |
|---|---|
| DrugBank ID | DB00773 |
| Drug Name | Etoposide |
| Target ID | BE0002425 |
| UniProt ID | Q02880 |
| Regulation Type | inhibitor |
| PubMed IDs | 17578914 |
| Citations | Azarova AM, Lyu YL, Lin CP, Tsai YC, Lau JY, Wang JC, Liu LF: Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11014-9. Epub 2007 Jun 19. |
| Groups | Approved |
| Direct Classification | Podophyllotoxins |
| SMILES | [H][C@]12COC(=O)[C@]1([H])[C@H](C1=CC(OC)=C(O)C(OC)=C1)C1=CC3=C(OCO3)C=C1[C@H]2O[C@@H]1O[C@]2([H])CO[C@@H](C)O[C@@]2([H])[C@H](O)[C@H]1O |
| Pathways | Etoposide Action Pathway; Etoposide Metabolism Pathway |
| PharmGKB | PA449552 |
| ChEMBL | CHEMBL44657 |
