| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30014871 | HIV | ENSG00000149554.15 | protein_coding | CHEK1 | No | Yes | 1111 | E7EPP6 O14757 |
| TVIS30006012 | HIV | ENSG00000149554.15 | protein_coding | CHEK1 | No | Yes | 1111 | E7EPP6 O14757 |
| TVIS30031527 | HIV | ENSG00000149554.15 | protein_coding | CHEK1 | No | Yes | 1111 | E7EPP6 O14757 |
| TVIS30031528 | HIV | ENSG00000149554.15 | protein_coding | CHEK1 | No | Yes | 1111 | E7EPP6 O14757 |
| TVIS30031529 | HIV | ENSG00000149554.15 | protein_coding | CHEK1 | No | Yes | 1111 | E7EPP6 O14757 |
| TVIS30031530 | HIV | ENSG00000149554.15 | protein_coding | CHEK1 | No | Yes | 1111 | E7EPP6 O14757 |
| TVIS30031531 | HIV | ENSG00000149554.15 | protein_coding | CHEK1 | No | Yes | 1111 | E7EPP6 O14757 |
| TVIS30031532 | HIV | ENSG00000149554.15 | protein_coding | CHEK1 | No | Yes | 1111 | E7EPP6 O14757 |
| TVIS30031533 | HIV | ENSG00000149554.15 | protein_coding | CHEK1 | No | Yes | 1111 | E7EPP6 O14757 |
| TVIS30031534 | HIV | ENSG00000149554.15 | protein_coding | CHEK1 | No | Yes | 1111 | E7EPP6 O14757 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CHEK1 |
|---|---|
| DrugBank ID | DB12008 |
| Drug Name | Prexasertib |
| Target ID | BE0003382 |
| UniProt ID | O14757 |
| Regulation Type | inhibitor |
| PubMed IDs | 30771522 |
| Citations | Hsu WH, Zhao X, Zhu J, Kim IK, Rao G, McCutcheon J, Hsu ST, Teicher B, Kallakury B, Dowlati A, Zhang YW, Giaccone G: Checkpoint Kinase 1 Inhibition Enhances Cisplatin Cytotoxicity and Overcomes Cisplatin Resistance in SCLC by Promoting Mitotic Cell Death. J Thorac Oncol. 2019 Jun;14(6):1032-1045. doi: 10.1016/j.jtho.2019.01.028. Epub 2019 Feb 14. |
| Groups | Investigational |
| Direct Classification | Phenylpyrazoles |
| SMILES | COC1=CC=CC(OCCCN)=C1C1=CC(NC2=CN=C(C=N2)C#N)=NN1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL3544911 |
