| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30014871 | HIV | ENSG00000149554.15 | protein_coding | CHEK1 | No | Yes | 1111 | E7EPP6 O14757 |
| TVIS30006012 | HIV | ENSG00000149554.15 | protein_coding | CHEK1 | No | Yes | 1111 | E7EPP6 O14757 |
| TVIS30031527 | HIV | ENSG00000149554.15 | protein_coding | CHEK1 | No | Yes | 1111 | E7EPP6 O14757 |
| TVIS30031528 | HIV | ENSG00000149554.15 | protein_coding | CHEK1 | No | Yes | 1111 | E7EPP6 O14757 |
| TVIS30031529 | HIV | ENSG00000149554.15 | protein_coding | CHEK1 | No | Yes | 1111 | E7EPP6 O14757 |
| TVIS30031530 | HIV | ENSG00000149554.15 | protein_coding | CHEK1 | No | Yes | 1111 | E7EPP6 O14757 |
| TVIS30031531 | HIV | ENSG00000149554.15 | protein_coding | CHEK1 | No | Yes | 1111 | E7EPP6 O14757 |
| TVIS30031532 | HIV | ENSG00000149554.15 | protein_coding | CHEK1 | No | Yes | 1111 | E7EPP6 O14757 |
| TVIS30031533 | HIV | ENSG00000149554.15 | protein_coding | CHEK1 | No | Yes | 1111 | E7EPP6 O14757 |
| TVIS30031534 | HIV | ENSG00000149554.15 | protein_coding | CHEK1 | No | Yes | 1111 | E7EPP6 O14757 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CHEK1 |
|---|---|
| DrugBank ID | DB12611 |
| Drug Name | PF-477736 |
| Target ID | BE0003382 |
| UniProt ID | O14757 |
| Regulation Type | inhibitor |
| PubMed IDs | 32610557 |
| Citations | Yang CY, Liu CR, Chang IY, OuYang CN, Hsieh CH, Huang YL, Wang CI, Jan FW, Wang WL, Tsai TL, Liu H, Tseng CP, Chang YS, Wu CC, Chang KP: Cotargeting CHK1 and PI3K Synergistically Suppresses Tumor Growth of Oral Cavity Squamous Cell Carcinoma in Patient-Derived Xenografts. Cancers (Basel). 2020 Jun 29;12(7). pii: cancers12071726. doi: 10.3390/cancers12071726. |
| Groups | Investigational |
| Direct Classification | Alpha amino acid amides |
| SMILES | CN1C=C(C=N1)C1=C2C=NNC(=O)C3=C2C(N1)=CC(NC(=O)[C@H](N)C1CCCCC1)=C3 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL3990456 |
