| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30067529 | HIV | ENSG00000070669.17 | protein_coding | ASNS | No | No | 440 | P08243 |
| TVIS30067530 | HIV | ENSG00000070669.17 | protein_coding | ASNS | No | No | 440 | P08243 |
| TVIS20001909 | HPV | ENSG00000070669.17 | protein_coding | ASNS | No | No | 440 | P08243 |
| TVIS44007056 | HTLV-1 | ENSG00000070669.17 | protein_coding | ASNS | No | No | 440 | P08243 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ASNS |
|---|---|
| DrugBank ID | DB00174 |
| Drug Name | Asparagine |
| Target ID | BE0000219 |
| UniProt ID | P08243 |
| Regulation Type | |
| PubMed IDs | 12706338; 14990305; 15574844; 16164412; 17380207 |
| Citations | Tesson AR, Soper TS, Ciustea M, Richards NG: Revisiting the steady state kinetic mechanism of glutamine-dependent asparagine synthetase from Escherichia coli. Arch Biochem Biophys. 2003 May 1;413(1):23-31.@@Fresquet V, Thoden JB, Holden HM, Raushel FM: Kinetic mechanism of asparagine synthetase from Vibrio cholerae. Bioorg Chem. 2004 Apr;32(2):63-75.@@Chaffei C, Pageau K, Suzuki A, Gouia H, Ghorbel MH, Masclaux-Daubresse C: Cadmium toxicity induced changes in nitrogen management in Lycopersicon esculentum leading to a metabolic safeguard through an amino acid storage strategy. Plant Cell Physiol. 2004 Nov;45(11):1681-93.@@Al Sarraj J, Vinson C, Thiel G: Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP. Biol Chem. 2005 Sep;386(9):873-9.@@Iwamoto S, Mihara K, Downing JR, Pui CH, Campana D: Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase. J Clin Invest. 2007 Apr;117(4):1049-57. Epub 2007 Mar 22. |
| Groups | Approved; Investigational; Nutraceutical |
| Direct Classification | Asparagine and derivatives |
| SMILES | N[C@@H](CC(N)=O)C(O)=O |
| Pathways | Clomocycline Action Pathway; Rolitetracycline Action Pathway; Demeclocycline Action Pathway; Josamycin Action Pathway; Gentamicin Action Pathway; Kanamycin Action Pathway; Canavan Disease; Hypoacetylaspartia; Tobramycin Action Pathway; Azithromycin Action Pathway; Clarithromycin Action Pathway; Minocycline Action Pathway; Lymecycline Action Pathway; Troleandomycin Action Pathway; Amikacin Action Pathway; Streptomycin Action Pathway; Oxytetracycline Action Pathway; Tetracycline Action Pathway; Spectinomycin Action Pathway; Erythromycin Action Pathway; Netilmicin Action Pathway; Doxycycline Action Pathway; Aspartate Metabolism; Telithromycin Action Pathway; Ammonia Recycling; Neomycin Action Pathway; Roxithromycin Action Pathway; Tigecycline Action Pathway; Arbekacin Action Pathway; Clindamycin Action Pathway |
| PharmGKB | PA164776968 |
| ChEMBL | CHEMBL58832 |
