| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30001381 | HIV | ENSG00000105810.10 | protein_coding | CDK6 | Yes | No | 1021 | Q00534 |
| TVIS30009361 | HIV | ENSG00000105810.10 | protein_coding | CDK6 | Yes | No | 1021 | Q00534 |
| TVIS30016523 | HIV | ENSG00000105810.10 | protein_coding | CDK6 | Yes | No | 1021 | Q00534 |
| TVIS30009362 | HIV | ENSG00000105810.10 | protein_coding | CDK6 | Yes | No | 1021 | Q00534 |
| TVIS30016524 | HIV | ENSG00000105810.10 | protein_coding | CDK6 | Yes | No | 1021 | Q00534 |
| TVIS30016525 | HIV | ENSG00000105810.10 | protein_coding | CDK6 | Yes | No | 1021 | Q00534 |
| TVIS30016526 | HIV | ENSG00000105810.10 | protein_coding | CDK6 | Yes | No | 1021 | Q00534 |
| TVIS30016527 | HIV | ENSG00000105810.10 | protein_coding | CDK6 | Yes | No | 1021 | Q00534 |
| TVIS30013556 | HIV | ENSG00000105810.10 | protein_coding | CDK6 | Yes | No | 1021 | Q00534 |
| TVIS30081163 | HIV | ENSG00000105810.10 | protein_coding | CDK6 | Yes | No | 1021 | Q00534 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CDK6 |
|---|---|
| DrugBank ID | DB09073 |
| Drug Name | Palbociclib |
| Target ID | BE0002212 |
| UniProt ID | Q00534 |
| Regulation Type | inhibitor |
| PubMed IDs | 15542782; 28203301 |
| Citations | Fry DW, Harvey PJ, Keller PR, Elliott WL, Meade M, Trachet E, Albassam M, Zheng X, Leopold WR, Pryer NK, Toogood PL: Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004 Nov;3(11):1427-38.@@Rocca A, Schirone A, Maltoni R, Bravaccini S, Cecconetto L, Farolfi A, Bronte G, Andreis D: Progress with palbociclib in breast cancer: latest evidence and clinical considerations. Ther Adv Med Oncol. 2017 Feb;9(2):83-105. doi: 10.1177/1758834016677961. Epub 2016 Nov 21. |
| Groups | Approved; Investigational |
| Direct Classification | Pyridinylpiperazines |
| SMILES | CC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N3CCNCC3)N=C2N(C2CCCC2)C1=O |
| Pathways | |
| PharmGKB | PA166153469 |
| ChEMBL | CHEMBL189963 |
