| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30001381 | HIV | ENSG00000105810.10 | protein_coding | CDK6 | Yes | No | 1021 | Q00534 |
| TVIS30009361 | HIV | ENSG00000105810.10 | protein_coding | CDK6 | Yes | No | 1021 | Q00534 |
| TVIS30016523 | HIV | ENSG00000105810.10 | protein_coding | CDK6 | Yes | No | 1021 | Q00534 |
| TVIS30009362 | HIV | ENSG00000105810.10 | protein_coding | CDK6 | Yes | No | 1021 | Q00534 |
| TVIS30016524 | HIV | ENSG00000105810.10 | protein_coding | CDK6 | Yes | No | 1021 | Q00534 |
| TVIS30016525 | HIV | ENSG00000105810.10 | protein_coding | CDK6 | Yes | No | 1021 | Q00534 |
| TVIS30016526 | HIV | ENSG00000105810.10 | protein_coding | CDK6 | Yes | No | 1021 | Q00534 |
| TVIS30016527 | HIV | ENSG00000105810.10 | protein_coding | CDK6 | Yes | No | 1021 | Q00534 |
| TVIS30013556 | HIV | ENSG00000105810.10 | protein_coding | CDK6 | Yes | No | 1021 | Q00534 |
| TVIS30081163 | HIV | ENSG00000105810.10 | protein_coding | CDK6 | Yes | No | 1021 | Q00534 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CDK6 |
|---|---|
| DrugBank ID | DB12001 |
| Drug Name | Abemaciclib |
| Target ID | BE0002212 |
| UniProt ID | Q00534 |
| Regulation Type | inhibitor |
| PubMed IDs | 24919854 |
| Citations | Gelbert LM, Cai S, Lin X, Sanchez-Martinez C, Del Prado M, Lallena MJ, Torres R, Ajamie RT, Wishart GN, Flack RS, Neubauer BL, Young J, Chan EM, Iversen P, Cronier D, Kreklau E, de Dios A: Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine. Invest New Drugs. 2014 Oct;32(5):825-37. doi: 10.1007/s10637-014-0120-7. Epub 2014 Jun 13. |
| Groups | Approved; Investigational |
| Direct Classification | Benzimidazoles |
| SMILES | CCN1CCN(CC2=CC=C(NC3=NC=C(F)C(=N3)C3=CC(F)=C4N=C(C)N(C(C)C)C4=C3)N=C2)CC1 |
| Pathways | |
| PharmGKB | PA166153471 |
| ChEMBL | CHEMBL3301610 |
