| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20028633 | HPV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS20027872 | HPV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS20070100 | HPV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS20027871 | HPV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS20069680 | HPV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS44022884 | HTLV-1 | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS44022885 | HTLV-1 | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS44020006 | HTLV-1 | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS44049194 | HTLV-1 | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS44045896 | HTLV-1 | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | LYN |
|---|---|
| DrugBank ID | DB08901 |
| Drug Name | Ponatinib |
| Target ID | BE0004315 |
| UniProt ID | P07948 |
| Regulation Type | inhibitor |
| PubMed IDs | 19878872 |
| Citations | O'Hare T, Shakespeare WC, Zhu X, Eide CA, Rivera VM, Wang F, Adrian LT, Zhou T, Huang WS, Xu Q, Metcalf CA 3rd, Tyner JW, Loriaux MM, Corbin AS, Wardwell S, Ning Y, Keats JA, Wang Y, Sundaramoorthi R, Thomas M, Zhou D, Snodgrass J, Commodore L, Sawyer TK, Dalgarno DC, Deininger MW, Druker BJ, Clackson T: AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 2009 Nov 6;16(5):401-12. doi: 10.1016/j.ccr.2009.09.028. |
| Groups | Approved; Investigational |
| Direct Classification | Benzanilides |
| SMILES | CN1CCN(CC2=CC=C(NC(=O)C3=CC(C#CC4=CN=C5C=CC=NN45)=C(C)C=C3)C=C2C(F)(F)F)CC1 |
| Pathways | Ponatinib Inhibition of BCR-ABL |
| PharmGKB | PA165980594 |
| ChEMBL | CHEMBL1171837 |
