| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS42001667 | EBV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS10010490 | HBV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS10011203 | HBV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS10011382 | HBV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS10001563 | HBV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS10023744 | HBV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS10031166 | HBV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS10049248 | HBV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS30068958 | HIV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS20007634 | HPV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | LYN |
|---|---|
| DrugBank ID | DB01254 |
| Drug Name | Dasatinib |
| Target ID | BE0004315 |
| UniProt ID | P07948 |
| Regulation Type | inhibitor |
| PubMed IDs | 18180381; 32268657 |
| Citations | Kneidinger M, Schmidt U, Rix U, Gleixner KV, Vales A, Baumgartner C, Lupinek C, Weghofer M, Bennett KL, Herrmann H, Schebesta A, Thomas WR, Vrtala S, Valenta R, Lee FY, Ellmeier W, Superti-Furga G, Valent P: The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood. 2008 Mar 15;111(6):3097-107. doi: 10.1182/blood-2007-08-104372. Epub 2008 Jan 7.@@Lee D, Park YH, Lee JE, Kim HS, Min KY, Jo MG, Kim HS, Choi WS, Kim YM: Dasatinib Inhibits Lyn and Fyn Src-Family Kinases in Mast Cells to Suppress Type I Hypersensitivity in Mice. Biomol Ther (Seoul). 2020 Sep 1;28(5):456-464. doi: 10.4062/biomolther.2020.013. |
| Groups | Approved; Investigational |
| Direct Classification | Aromatic anilides |
| SMILES | CC1=NC(NC2=NC=C(S2)C(=O)NC2=C(C)C=CC=C2Cl)=CC(=N1)N1CCN(CCO)CC1 |
| Pathways | Dasatinib Inhibition of BCR-ABL |
| PharmGKB | PA162372878 |
| ChEMBL | CHEMBL1421 |
