| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20070029 | HPV | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
| TVIS20028064 | HPV | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
| TVIS20069518 | HPV | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
| TVIS20030467 | HPV | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
| TVIS20028056 | HPV | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
| TVIS20069519 | HPV | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
| TVIS20064299 | HPV | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
| TVIS20028053 | HPV | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
| TVIS20069520 | HPV | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
| TVIS20064235 | HPV | ENSG00000101868.13 | protein_coding | POLA1 | No | No | 5422 | A6NMQ1 P09884 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | POLA1 |
|---|---|
| DrugBank ID | DB01280 |
| Drug Name | Nelarabine |
| Target ID | BE0000546 |
| UniProt ID | P09884 |
| Regulation Type | inhibitor |
| PubMed IDs | 91427; 18035189; 18473971; 12750168 |
| Citations | Ono K, Ohashi A, Yamamoto A, Matsukage A, Takahasi T, Saneyoshi M, Ueda T: Inhibitory effects of 9-beta-D-arabinofuranosylguanine 5'-triphosphate and 9-beta-D-arabinofuranosyladenine 5'-triphosphate on DNA polymerases from murine cells and oncornavirus. Cancer Res. 1979 Nov;39(11):4673-80.@@Buie LW, Epstein SS, Lindley CM: Nelarabine: a novel purine antimetabolite antineoplastic agent. Clin Ther. 2007 Sep;29(9):1887-99.@@Curbo S, Karlsson A: Nelarabine: a new purine analog in the treatment of hematologic malignancies. Rev Recent Clin Trials. 2006 Sep;1(3):185-92.@@Rodriguez CO Jr, Stellrecht CM, Gandhi V: Mechanisms for T-cell selective cytotoxicity of arabinosylguanine. Blood. 2003 Sep 1;102(5):1842-8. Epub 2003 May 15. |
| Groups | Approved; Investigational |
| Direct Classification | Purine nucleosides |
| SMILES | COC1=NC(N)=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O |
| Pathways | |
| PharmGKB | PA164752425 |
| ChEMBL | CHEMBL1201112 |
