| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30013303 | HIV | ENSG00000132356.12 | protein_coding | PRKAA1 | No | No | 5562 | Q13131 |
| TVIS30062198 | HIV | ENSG00000132356.12 | protein_coding | PRKAA1 | No | No | 5562 | Q13131 |
| TVIS44012745 | HTLV-1 | ENSG00000132356.12 | protein_coding | PRKAA1 | No | No | 5562 | Q13131 |
| TVIS44050461 | HTLV-1 | ENSG00000132356.12 | protein_coding | PRKAA1 | No | No | 5562 | Q13131 |
| TVIS44050462 | HTLV-1 | ENSG00000132356.12 | protein_coding | PRKAA1 | No | No | 5562 | Q13131 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PRKAA1 |
|---|---|
| DrugBank ID | DB00914 |
| Drug Name | Phenformin |
| Target ID | BE0000677 |
| UniProt ID | Q13131 |
| Regulation Type | activator |
| PubMed IDs | 17603555; 17995453; 17369473 |
| Citations | Woollhead AM, Sivagnanasundaram J, Kalsi KK, Pucovsky V, Pellatt LJ, Scott JW, Mustard KJ, Hardie DG, Baines DL: Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells. Br J Pharmacol. 2007 Aug;151(8):1204-15. Epub 2007 Jul 2.@@Chen S, Murphy J, Toth R, Campbell DG, Morrice NA, Mackintosh C: Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators. Biochem J. 2008 Jan 15;409(2):449-59.@@Zhang L, He H, Balschi JA: Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H457-66. Epub 2007 Mar 16. |
| Groups | Approved; Investigational; Withdrawn |
| Direct Classification | Biguanides |
| SMILES | NC(=N)NC(=N)NCCC1=CC=CC=C1 |
| Pathways | |
| PharmGKB | PA1000 |
| ChEMBL | CHEMBL170988 |
