| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30013303 | HIV | ENSG00000132356.12 | protein_coding | PRKAA1 | No | No | 5562 | Q13131 |
| TVIS30062198 | HIV | ENSG00000132356.12 | protein_coding | PRKAA1 | No | No | 5562 | Q13131 |
| TVIS44012745 | HTLV-1 | ENSG00000132356.12 | protein_coding | PRKAA1 | No | No | 5562 | Q13131 |
| TVIS44050461 | HTLV-1 | ENSG00000132356.12 | protein_coding | PRKAA1 | No | No | 5562 | Q13131 |
| TVIS44050462 | HTLV-1 | ENSG00000132356.12 | protein_coding | PRKAA1 | No | No | 5562 | Q13131 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PRKAA1 |
|---|---|
| DrugBank ID | DB00945 |
| Drug Name | Acetylsalicylic acid |
| Target ID | BE0004907 |
| UniProt ID | Q9UGI9 |
| Regulation Type | activator |
| PubMed IDs | 22406476; 22517326; 23871515 |
| Citations | Din FV, Valanciute A, Houde VP, Zibrova D, Green KA, Sakamoto K, Alessi DR, Dunlop MG: Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells. Gastroenterology. 2012 Jun;142(7):1504-15.e3. doi: 10.1053/j.gastro.2012.02.050. Epub 2012 Mar 6.@@Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ, Peggie MW, Zibrova D, Green KA, Mustard KJ, Kemp BE, Sakamoto K, Steinberg GR, Hardie DG: The ancient drug salicylate directly activates AMP-activated protein kinase. Science. 2012 May 18;336(6083):918-22. doi: 10.1126/science.1215327. Epub 2012 Apr 19.@@Steinberg GR, Dandapani M, Hardie DG: AMPK: mediating the metabolic effects of salicylate-based drugs? Trends Endocrinol Metab. 2013 Oct;24(10):481-7. doi: 10.1016/j.tem.2013.06.002. Epub 2013 Jul 19. |
| Groups | Approved; Vet_approved |
| Direct Classification | Acylsalicylic acids |
| SMILES | CC(=O)OC1=CC=CC=C1C(O)=O |
| Pathways | Acetylsalicylic Acid Action Pathway |
| PharmGKB | PA448497 |
| ChEMBL | CHEMBL25 |
