| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10017602 | HBV | ENSG00000160868.16 | protein_coding | CYP3A4 | No | No | 1576 | P08684 Q6GRK0 |
| TVIS10009001 | HBV | ENSG00000160868.16 | protein_coding | CYP3A4 | No | No | 1576 | P08684 Q6GRK0 |
| TVIS10019432 | HBV | ENSG00000160868.16 | protein_coding | CYP3A4 | No | No | 1576 | P08684 Q6GRK0 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CYP3A4 |
|---|---|
| DrugBank ID | DB09065 |
| Drug Name | Cobicistat |
| Target ID | BE0002638 |
| UniProt ID | P08684 |
| Regulation Type | inhibitor |
| PubMed IDs | 20043009; 28060009; 26935921 |
| Citations | Mathias AA, German P, Murray BP, Wei L, Jain A, West S, Warren D, Hui J, Kearney BP: Pharmacokinetics and pharmacodynamics of GS-9350: a novel pharmacokinetic enhancer without anti-HIV activity. Clin Pharmacol Ther. 2010 Mar;87(3):322-9. doi: 10.1038/clpt.2009.228. Epub 2009 Dec 30.@@Nanda K, Stuart GS, Robinson J, Gray AL, Tepper NK, Gaffield ME: Drug interactions between hormonal contraceptives and antiretrovirals. AIDS. 2017 Apr 24;31(7):917-952. doi: 10.1097/QAD.0000000000001392.@@Wang P, Shehu AI, Liu K, Lu J, Ma X: Biotransformation of Cobicistat: Metabolic Pathways and Enzymes. Drug Metab Lett. 2016;10(2):111-23. |
| Groups | Approved |
| Direct Classification | N-carbamoyl-alpha amino acids and derivatives |
| SMILES | CC(C)C1=NC(CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC2=CC=CC=C2)NC(=O)OCC2=CN=CS2)CC2=CC=CC=C2)=CS1 |
| Pathways | |
| PharmGKB | PA166165092 |
| ChEMBL | CHEMBL2095208 |
