| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS42001682 | EBV | ENSG00000005844.19 | protein_coding | ITGAL | No | No | 3683 | P20701 |
| TVIS30006844 | HIV | ENSG00000005844.19 | protein_coding | ITGAL | No | No | 3683 | P20701 |
| TVIS30012119 | HIV | ENSG00000005844.19 | protein_coding | ITGAL | No | No | 3683 | P20701 |
| TVIS30012120 | HIV | ENSG00000005844.19 | protein_coding | ITGAL | No | No | 3683 | P20701 |
| TVIS30002480 | HIV | ENSG00000005844.19 | protein_coding | ITGAL | No | No | 3683 | P20701 |
| TVIS30002481 | HIV | ENSG00000005844.19 | protein_coding | ITGAL | No | No | 3683 | P20701 |
| TVIS30006845 | HIV | ENSG00000005844.19 | protein_coding | ITGAL | No | No | 3683 | P20701 |
| TVIS30012121 | HIV | ENSG00000005844.19 | protein_coding | ITGAL | No | No | 3683 | P20701 |
| TVIS30006846 | HIV | ENSG00000005844.19 | protein_coding | ITGAL | No | No | 3683 | P20701 |
| TVIS30006847 | HIV | ENSG00000005844.19 | protein_coding | ITGAL | No | No | 3683 | P20701 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ITGAL |
|---|---|
| DrugBank ID | DB01098 |
| Drug Name | Rosuvastatin |
| Target ID | BE0000516 |
| UniProt ID | P20701 |
| Regulation Type | inhibitory allosteric modulator |
| PubMed IDs | 11385505; 15041742; 15822172 |
| Citations | Weitz-Schmidt G, Welzenbach K, Brinkmann V, Kamata T, Kallen J, Bruns C, Cottens S, Takada Y, Hommel U: Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat Med. 2001 Jun;7(6):687-92. doi: 10.1038/89058.@@Katano H, Pesnicak L, Cohen JI: Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4960-5. Epub 2004 Mar 23.@@Liao JK, Laufs U: Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol. 2005;45:89-118. doi: 10.1146/annurev.pharmtox.45.120403.095748. |
| Groups | Approved |
| Direct Classification | Phenylpyrimidines |
| SMILES | CC(C)C1=NC(=NC(C2=CC=C(F)C=C2)=C1C=C[C@@H](O)C[C@@H](O)CC(=O)O)N(C)S(C)(=O)=O |
| Pathways | Rosuvastatin Action Pathway |
| PharmGKB | PA134308647 |
| ChEMBL | CHEMBL1496 |
