| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS42001667 | EBV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS10010490 | HBV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS10011203 | HBV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS10011382 | HBV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS10001563 | HBV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS10023744 | HBV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS10031166 | HBV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS10049248 | HBV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS30068958 | HIV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
| TVIS20007634 | HPV | ENSG00000254087.8 | protein_coding | LYN | Yes | No | 4067 | P07948 Q6NUK7 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | LYN |
|---|---|
| DrugBank ID | DB09079 |
| Drug Name | Nintedanib |
| Target ID | BE0004315 |
| UniProt ID | P07948 |
| Regulation Type | inhibitor |
| PubMed IDs | 18559524; 31016670 |
| Citations | Hilberg F, Roth GJ, Krssak M, Kautschitsch S, Sommergruber W, Tontsch-Grunt U, Garin-Chesa P, Bader G, Zoephel A, Quant J, Heckel A, Rettig WJ: BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res. 2008 Jun 15;68(12):4774-82. doi: 10.1158/0008-5472.CAN-07-6307.@@Wind S, Schmid U, Freiwald M, Marzin K, Lotz R, Ebner T, Stopfer P, Dallinger C: Clinical Pharmacokinetics and Pharmacodynamics of Nintedanib. Clin Pharmacokinet. 2019 Sep;58(9):1131-1147. doi: 10.1007/s40262-019-00766-0. |
| Groups | Approved |
| Direct Classification | Indolecarboxylic acids |
| SMILES | COC(=O)C1=CC=C2C(NC(=O)C2=C(/NC2=CC=C(C=C2)N(C)C(=O)CN2CCN(C)CC2)C2=CC=CC=C2)=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL502835 |
