| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30004337 | HIV | ENSG00000117400.18 | protein_coding | MPL | Yes | No | 4352 | P40238 |
| TVIS30023463 | HIV | ENSG00000117400.18 | protein_coding | MPL | Yes | No | 4352 | P40238 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | MPL |
|---|---|
| DrugBank ID | DB13125 |
| Drug Name | Lusutrombopag |
| Target ID | BE0003440 |
| UniProt ID | P40238 |
| Regulation Type | agonist |
| PubMed IDs | 29274361; 26666417 |
| Citations | Yoshida H, Yamada H, Nogami W, Dohi K, Kurino-Yamada T, Sugiyama K, Takahashi K, Gahara Y, Kitaura M, Hasegawa M, Oshima I, Kuwabara K: Development of a new knock-in mouse model and evaluation of pharmacological activities of lusutrombopag, a novel, nonpeptidyl small-molecule agonist of the human thrombopoietin receptor c-Mpl. Exp Hematol. 2018 Mar;59:30-39.e2. doi: 10.1016/j.exphem.2017.12.005. Epub 2017 Dec 20.@@Kim ES: Lusutrombopag: First Global Approval. Drugs. 2016 Jan;76(1):155-8. doi: 10.1007/s40265-015-0525-4. |
| Groups | Approved; Investigational |
| Direct Classification | Cinnamic acids |
| SMILES | CCCCCCO[C@@H](C)C1=C(OC)C(=CC=C1)C1=CSC(NC(=O)C2=CC(Cl)=C(C=C(/C)C(O)=O)C(Cl)=C2)=N1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL2107831 |
