| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30059022 | HIV | ENSG00000121879.6 | protein_coding | PIK3CA | Yes | No | 5290 | P42336 Q4LE51 |
| TVIS20008729 | HPV | ENSG00000121879.6 | protein_coding | PIK3CA | Yes | No | 5290 | P42336 Q4LE51 |
| TVIS20057196 | HPV | ENSG00000121879.6 | protein_coding | PIK3CA | Yes | No | 5290 | P42336 Q4LE51 |
| TVIS20056575 | HPV | ENSG00000121879.6 | protein_coding | PIK3CA | Yes | No | 5290 | P42336 Q4LE51 |
| TVIS20019982 | HPV | ENSG00000121879.6 | protein_coding | PIK3CA | Yes | No | 5290 | P42336 Q4LE51 |
| TVIS20019983 | HPV | ENSG00000121879.6 | protein_coding | PIK3CA | Yes | No | 5290 | P42336 Q4LE51 |
| TVIS20019984 | HPV | ENSG00000121879.6 | protein_coding | PIK3CA | Yes | No | 5290 | P42336 Q4LE51 |
| TVIS44000358 | HTLV-1 | ENSG00000121879.6 | protein_coding | PIK3CA | Yes | No | 5290 | P42336 Q4LE51 |
| TVIS44005997 | HTLV-1 | ENSG00000121879.6 | protein_coding | PIK3CA | Yes | No | 5290 | P42336 Q4LE51 |
| TVIS44030971 | HTLV-1 | ENSG00000121879.6 | protein_coding | PIK3CA | Yes | No | 5290 | P42336 Q4LE51 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | PIK3CA |
|---|---|
| DrugBank ID | DB12015 |
| Drug Name | Alpelisib |
| Target ID | BE0002379 |
| UniProt ID | P42336 |
| Regulation Type | inhibitor |
| PubMed IDs | 28852212; 29109464 |
| Citations | Chen IC, Hsiao LP, Huang IW, Yu HC, Yeh LC, Lin CH, Wei-Wu Chen T, Cheng AL, Lu YS: Phosphatidylinositol-3 Kinase Inhibitors, Buparlisib and Alpelisib, Sensitize Estrogen Receptor-positive Breast Cancer Cells to Tamoxifen. Sci Rep. 2017 Aug 29;7(1):9842. doi: 10.1038/s41598-017-10555-z.@@Yang X, Zhang X, Huang M, Song K, Li X, Huang M, Meng L, Zhang J: New Insights into PI3K Inhibitor Design using X-ray Structures of PI3Kalpha Complexed with a Potent Lead Compound. Sci Rep. 2017 Nov 6;7(1):14572. doi: 10.1038/s41598-017-15260-5. |
| Groups | Approved; Investigational |
| Direct Classification | Proline and derivatives |
| SMILES | CC1=C(SC(NC(=O)N2CCC[C@H]2C(N)=O)=N1)C1=CC(=NC=C1)C(C)(C)C(F)(F)F |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL2396661 |
