| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10004907 | HBV | ENSG00000070915.10 | protein_coding | SLC12A3 | No | No | 6559 | J3QSS1 P55017 |
| TVIS10002672 | HBV | ENSG00000070915.10 | protein_coding | SLC12A3 | No | No | 6559 | J3QSS1 P55017 |
| TVIS10022547 | HBV | ENSG00000070915.10 | protein_coding | SLC12A3 | No | No | 6559 | J3QSS1 P55017 |
| TVIS10027635 | HBV | ENSG00000070915.10 | protein_coding | SLC12A3 | No | No | 6559 | J3QSS1 P55017 |
| TVIS10049843 | HBV | ENSG00000070915.10 | protein_coding | SLC12A3 | No | No | 6559 | J3QSS1 P55017 |
| TVIS30041140 | HIV | ENSG00000070915.10 | protein_coding | SLC12A3 | No | No | 6559 | J3QSS1 P55017 |
| TVIS20052662 | HPV | ENSG00000070915.10 | protein_coding | SLC12A3 | No | No | 6559 | J3QSS1 P55017 |
| TVIS44023796 | HTLV-1 | ENSG00000070915.10 | protein_coding | SLC12A3 | No | No | 6559 | J3QSS1 P55017 |
| TVIS44023797 | HTLV-1 | ENSG00000070915.10 | protein_coding | SLC12A3 | No | No | 6559 | J3QSS1 P55017 |
| TVIS44047476 | HTLV-1 | ENSG00000070915.10 | protein_coding | SLC12A3 | No | No | 6559 | J3QSS1 P55017 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SLC12A3 |
|---|---|
| DrugBank ID | DB00999 |
| Drug Name | Hydrochlorothiazide |
| Target ID | BE0000419 |
| UniProt ID | P55017 |
| Regulation Type | inhibitor |
| PubMed IDs | 11752352; 16078592; 16172412; 9596079; 9038817; 12772080; 10894798 |
| Citations | Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Ran XW, Wang C, Dai F, Jiang JJ, Tong NW, Li XJ, Liang JZ: [A case of Gitelman's syndrome presenting with severe hypocalcaemia and hypokalemic periodic paralysis]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 Jul;36(4):583-7.@@Turner ST, Schwartz GL, Chapman AB, Boerwinkle E: WNK1 kinase polymorphism and blood pressure response to a thiazide diuretic. Hypertension. 2005 Oct;46(4):758-65. Epub 2005 Sep 19.@@Abuladze N, Yanagawa N, Lee I, Jo OD, Newman D, Hwang J, Uyemura K, Pushkin A, Modlin RL, Kurtz I: Peripheral blood mononuclear cells express mutated NCCT mRNA in Gitelman's syndrome: evidence for abnormal thiazide-sensitive NaCl cotransport. J Am Soc Nephrol. 1998 May;9(5):819-26.@@Barry EL, Gesek FA, Kaplan MR, Hebert SC, Friedman PA: Expression of the sodium-chloride cotransporter in osteoblast-like cells: effect of thiazide diuretics. Am J Physiol. 1997 Jan;272(1 Pt 1):C109-16.@@Kurschat C, Heering P, Grabensee B: [Gitelman's syndrome: an important differential diagnosis of hypokalemia]. Dtsch Med Wochenschr. 2003 May 30;128(22):1225-8.@@Monroy A, Plata C, Hebert SC, Gamba G: Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction. Am J Physiol Renal Physiol. 2000 Jul;279(1):F161-9. |
| Groups | Approved; Vet_approved |
| Direct Classification | 1,2,4-benzothiadiazine-1,1-dioxides |
| SMILES | NS(=O)(=O)C1=C(Cl)C=C2NCNS(=O)(=O)C2=C1 |
| Pathways | Hydrochlorothiazide Action Pathway |
| PharmGKB | PA449899 |
| ChEMBL | CHEMBL435 |
