| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20043167 | HPV | ENSG00000171094.18 | protein_coding | ALK | Yes | No | 238 | B6D4Y2 Q9UM73 |
| TVIS20055124 | HPV | ENSG00000171094.18 | protein_coding | ALK | Yes | No | 238 | B6D4Y2 Q9UM73 |
| TVIS20045061 | HPV | ENSG00000171094.18 | protein_coding | ALK | Yes | No | 238 | B6D4Y2 Q9UM73 |
| TVIS20054251 | HPV | ENSG00000171094.18 | protein_coding | ALK | Yes | No | 238 | B6D4Y2 Q9UM73 |
| TVIS20055059 | HPV | ENSG00000171094.18 | protein_coding | ALK | Yes | No | 238 | B6D4Y2 Q9UM73 |
| TVIS20054259 | HPV | ENSG00000171094.18 | protein_coding | ALK | Yes | No | 238 | B6D4Y2 Q9UM73 |
| TVIS20055046 | HPV | ENSG00000171094.18 | protein_coding | ALK | Yes | No | 238 | B6D4Y2 Q9UM73 |
| TVIS20041515 | HPV | ENSG00000171094.18 | protein_coding | ALK | Yes | No | 238 | B6D4Y2 Q9UM73 |
| TVIS20018853 | HPV | ENSG00000171094.18 | protein_coding | ALK | Yes | No | 238 | B6D4Y2 Q9UM73 |
| TVIS20055117 | HPV | ENSG00000171094.18 | protein_coding | ALK | Yes | No | 238 | B6D4Y2 Q9UM73 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ALK |
|---|---|
| DrugBank ID | DB12267 |
| Drug Name | Brigatinib |
| Target ID | BE0000359 |
| UniProt ID | Q9UM73 |
| Regulation Type | inhibitor |
| PubMed IDs | 23239810; 25888090; 28597393 |
| Citations | Ceccon M, Mologni L, Bisson W, Scapozza L, Gambacorti-Passerini C: Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors. Mol Cancer Res. 2013 Feb;11(2):122-32. doi: 10.1158/1541-7786.MCR-12-0569. Epub 2012 Dec 13.@@Iragavarapu C, Mustafa M, Akinleye A, Furqan M, Mittal V, Cang S, Liu D: Novel ALK inhibitors in clinical use and development. J Hematol Oncol. 2015 Feb 27;8:17. doi: 10.1186/s13045-015-0122-8.@@Markham A: Brigatinib: First Global Approval. Drugs. 2017 Jul;77(10):1131-1135. doi: 10.1007/s40265-017-0776-3. |
| Groups | Approved; Investigational |
| Direct Classification | Phenylpiperidines |
| SMILES | COC1=CC(=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1)N1CCC(CC1)N1CCN(C)CC1 |
| Pathways | |
| PharmGKB | PA166163482 |
| ChEMBL | CHEMBL3545311 |
