Target Gene Table ▼
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS42001004EBVENSG00000140009.19protein_codingESR2NoNo2100Q92731
TVIS10045761HBVENSG00000140009.19protein_codingESR2NoNo2100Q92731
TVIS10045762HBVENSG00000140009.19protein_codingESR2NoNo2100Q92731
TVIS30036598HIVENSG00000140009.19protein_codingESR2NoNo2100Q92731
TVIS30036599HIVENSG00000140009.19protein_codingESR2NoNo2100Q92731
TVIS30036600HIVENSG00000140009.19protein_codingESR2NoNo2100Q92731
TVIS30036601HIVENSG00000140009.19protein_codingESR2NoNo2100Q92731
TVIS20017167HPVENSG00000140009.19protein_codingESR2NoNo2100Q92731
TVIS20051518HPVENSG00000140009.19protein_codingESR2NoNo2100Q92731
TVIS20034451HPVENSG00000140009.19protein_codingESR2NoNo2100Q92731
TCGA Plot Options ▼
Drug Information ▼
GeneESR2
DrugBank IDDB01108
Drug NameTrilostane
Target IDBE0000792
UniProt IDQ92731
Regulation Typeallosteric modulator
PubMed IDs17109615; 12209583; 16806905
CitationsPuddefoot JR, Barker S, Vinson GP: Trilostane in advanced breast cancer. Expert Opin Pharmacother. 2006 Dec;7(17):2413-9.@@Puddefoot JR, Barker S, Glover HR, Malouitre SD, Vinson GP: Non-competitive steroid inhibition of oestrogen receptor functions. Int J Cancer. 2002 Sep 1;101(1):17-22.@@Barker S, Malouitre SD, Glover HR, Puddefoot JR, Vinson GP: Comparison of effects of 4-hydroxy tamoxifen and trilostane on oestrogen-regulated gene expression in MCF-7 cells: up-regulation of oestrogen receptor beta. J Steroid Biochem Mol Biol. 2006 Aug;100(4-5):141-51. Epub 2006 Jun 27.
GroupsApproved; Investigational; Vet_approved; Withdrawn
Direct ClassificationEstrane steroids
SMILES[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]23O[C@@H]2C(O)=C(C[C@]13C)C#N
Pathways
PharmGKBPA164748507
ChEMBLCHEMBL1200907