Target Gene Table
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS10009296HBVENSG00000143257.12protein_codingNR1I3NoNo9970F1DAL4
Q14994
TCGA Plot Options
Drug Information
GeneNR1I3
DrugBank IDDB04540
Drug NameCholesterol
Target IDBE0003848
UniProt IDQ14994
Regulation Type
PubMed IDs16051528
CitationsMooijaart SP, Brandt BW, Baldal EA, Pijpe J, Kuningas M, Beekman M, Zwaan BJ, Slagboom PE, Westendorp RG, van Heemst D: C. elegans DAF-12, Nuclear Hormone Receptors and human longevity and disease at old age. Ageing Res Rev. 2005 Aug;4(3):351-71.
GroupsApproved; Investigational
Direct ClassificationCholesterols and derivatives
SMILES[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C
PathwaysCerivastatin Action Pathway; 3-beta-Hydroxysteroid Dehydrogenase Deficiency; Pamidronate Action Pathway; Ibandronate Action Pathway; Simvastatin Action Pathway; Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2); Smith-Lemli-Opitz Syndrome (SLOS); Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH; Zellweger Syndrome; Lysosomal Acid Lipase Deficiency (Wolman Disease); Steroid Biosynthesis; Hypercholesterolemia; Risedronate Action Pathway; Mevalonic Aciduria; Congenital Bile Acid Synthesis Defect Type II; Apparent Mineralocorticoid Excess Syndrome; Rosuvastatin Action Pathway; Alendronate Action Pathway; Zoledronate Action Pathway; 11-beta-Hydroxylase Deficiency (CYP11B1); Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency; Cholesteryl Ester Storage Disease; Lovastatin Action Pathway; Bile Acid Biosynthesis; Corticosterone Methyl Oxidase I Deficiency (CMO I); 27-Hydroxylase Deficiency; Steroidogenesis; Fluvastatin Action Pathway; Atorvastatin Action Pathway; Pravastatin Action Pathway
PharmGKB
ChEMBLCHEMBL112570