| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10060266 | HBV | ENSG00000167315.18 | protein_coding | ACAA2 | No | No | 10449 | P42765 |
| TVIS10060265 | HBV | ENSG00000167315.18 | protein_coding | ACAA2 | No | No | 10449 | P42765 |
| TVIS30007327 | HIV | ENSG00000167315.18 | protein_coding | ACAA2 | No | No | 10449 | P42765 |
| TVIS30012471 | HIV | ENSG00000167315.18 | protein_coding | ACAA2 | No | No | 10449 | P42765 |
| TVIS44021235 | HTLV-1 | ENSG00000167315.18 | protein_coding | ACAA2 | No | No | 10449 | P42765 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ACAA2 |
|---|---|
| DrugBank ID | DB09069 |
| Drug Name | Trimetazidine |
| Target ID | BE0010052 |
| UniProt ID | P42765 |
| Regulation Type | inhibitor |
| PubMed IDs | 11286307; 11286305; 10720420; 11286302; 25756467; 12869391 |
| Citations | Lopaschuk GD: Optimizing cardiac energy metabolism: how can fatty acid and carbohydrate metabolism be manipulated? Coron Artery Dis. 2001 Feb;12 Suppl 1:S8-11.@@Pogatsa G: Metabolic energy metabolism in diabetes: therapeutic implications. Coron Artery Dis. 2001 Feb;12 Suppl 1:S29-33.@@Kantor PF, Lucien A, Kozak R, Lopaschuk GD: The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res. 2000 Mar 17;86(5):580-8.@@Chierchia SL: Dobutamine stress echocardiography and the effects of trimetazidine on left ventricular dysfunction in patients with coronary artery disease. Coron Artery Dis. 2001 Feb;12 Suppl 1:S19-21.@@Dezsi CA: Trimetazidine in Practice: Review of the Clinical and Experimental Evidence. Am J Ther. 2016 May-Jun;23(3):e871-9. doi: 10.1097/MJT.0000000000000180.@@MacInnes A, Fairman DA, Binding P, Rhodes Ja, Wyatt MJ, Phelan A, Haddock PS, Karran EH: The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res. 2003 Aug 8;93(3):e26-32. doi: 10.1161/01.RES.0000086943.72932.71. Epub 2003 Jul 17. |
| Groups | Approved; Investigational |
| Direct Classification | Phenylmethylamines |
| SMILES | COC1=C(OC)C(OC)=C(CN2CCNCC2)C=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL203266 |
