| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10017785 | HBV | ENSG00000110881.12 | protein_coding | ASIC1 | No | No | 41 | P78348 |
| TVIS30088365 | HIV | ENSG00000110881.12 | protein_coding | ASIC1 | No | No | 41 | P78348 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ASIC1 |
|---|---|
| DrugBank ID | DB00594 |
| Drug Name | Amiloride |
| Target ID | BE0000353 |
| UniProt ID | P78348 |
| Regulation Type | inhibitor |
| PubMed IDs | 12401318; 15574747; 15758172; 16319075; 16685601 |
| Citations | Petruska JC, Napaporn J, Johnson RD, Cooper BY: Chemical responsiveness and histochemical phenotype of electrophysiologically classified cells of the adult rat dorsal root ganglion. Neuroscience. 2002;115(1):15-30.@@Jones NG, Slater R, Cadiou H, McNaughton P, McMahon SB: Acid-induced pain and its modulation in humans. J Neurosci. 2004 Dec 1;24(48):10974-9.@@Sugiura T, Dang K, Lamb K, Bielefeldt K, Gebhart GF: Acid-sensing properties in rat gastric sensory neurons from normal and ulcerated stomach. J Neurosci. 2005 Mar 9;25(10):2617-27.@@Wang W, Duan B, Xu H, Xu L, Xu TL: Calcium-permeable acid-sensing ion channel is a molecular target of the neurotoxic metal ion lead. J Biol Chem. 2006 Feb 3;281(5):2497-505. Epub 2005 Nov 29.@@Xiong ZG, Chu XP, Simon RP: Ca2+ -permeable acid-sensing ion channels and ischemic brain injury. J Membr Biol. 2006 Jan;209(1):59-68. Epub 2006 Apr 17. |
| Groups | Approved |
| Direct Classification | Aminopyrazines |
| SMILES | NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N |
| Pathways | Amiloride Action Pathway |
| PharmGKB | PA448368 |
| ChEMBL | CHEMBL945 |
