| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30007896 | HIV | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
| TVIS30052334 | HIV | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
| TVIS30052335 | HIV | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
| TVIS44037937 | HTLV-1 | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
| TVIS44037738 | HTLV-1 | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
| TVIS44037936 | HTLV-1 | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
| TVIS44044411 | HTLV-1 | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
| TVIS44037935 | HTLV-1 | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | ATIC |
|---|---|
| DrugBank ID | DB00116 |
| Drug Name | Tetrahydrofolic acid |
| Target ID | BE0001240 |
| UniProt ID | P31939 |
| Regulation Type | cofactor |
| PubMed IDs | 12974624; 11948179 |
| Citations | Wolan DW, Greasley SE, Wall MJ, Benkovic SJ, Wilson IA: Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site. Biochemistry. 2003 Sep 23;42(37):10904-14.@@Bulock KG, Beardsley GP, Anderson KS: The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling. J Biol Chem. 2002 Jun 21;277(25):22168-74. Epub 2002 Apr 10. |
| Groups | Nutraceutical |
| Direct Classification | Glutamic acid and derivatives |
| SMILES | NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2)N1 |
| Pathways | Histidinemia; Lesch-Nyhan Syndrome (LNS); Molybdenum Cofactor Deficiency; Azathioprine Action Pathway; AICA-Ribosiduria; Purine Nucleoside Phosphorylase Deficiency; Methionine Adenosyltransferase Deficiency; Folate Malabsorption, Hereditary; Adenine Phosphoribosyltransferase Deficiency (APRT); Thioguanine Action Pathway; Mercaptopurine Action Pathway; Non-Ketotic Hyperglycinemia; Methotrexate Action Pathway; Betaine Metabolism; S-Adenosylhomocysteine (SAH) Hydrolase Deficiency; Glycine and Serine Metabolism; Adenosine Deaminase Deficiency; Xanthinuria Type II; Methionine Metabolism; Dihydropyrimidine Dehydrogenase Deficiency (DHPD); Histidine Metabolism; Cystathionine beta-Synthase Deficiency; Folate Metabolism; Sarcosine Oncometabolite Pathway; Sarcosinemia; Methylenetetrahydrofolate Reductase Deficiency (MTHFRD); Purine Metabolism; Gout or Kelley-Seegmiller Syndrome; Adenylosuccinate Lyase Deficiency; Ammonia Recycling |
| PharmGKB | PA164745110 |
| ChEMBL | CHEMBL2021342 |
