| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20008608 | HPV | ENSG00000167434.10 | protein_coding | CA4 | No | No | 762 | P22748 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CA4 |
|---|---|
| DrugBank ID | DB00232 |
| Drug Name | Methyclothiazide |
| Target ID | BE0000535 |
| UniProt ID | P22748 |
| Regulation Type | inhibitor |
| PubMed IDs | 10713865; 19119014 |
| Citations | Puscas I, Coltau M, Baican M, Domuta G, Hecht A: Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action. Drugs Exp Clin Res. 1999;25(6):271-9.@@Temperini C, Cecchi A, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference. Bioorg Med Chem. 2009 Feb 1;17(3):1214-21. doi: 10.1016/j.bmc.2008.12.023. Epub 2008 Dec 24. |
| Groups | Withdrawn |
| Direct Classification | 1,2,4-benzothiadiazine-1,1-dioxides |
| SMILES | CN1C(CCl)NC2=CC(Cl)=C(C=C2S1(=O)=O)S(N)(=O)=O |
| Pathways | Methyclothiazide Action Pathway |
| PharmGKB | PA164748094 |
| ChEMBL | CHEMBL1577 |
