| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10041973 | HBV | ENSG00000174990.8 | protein_coding | CA5A | No | No | 763 | P35218 |
| TVIS30084270 | HIV | ENSG00000174990.8 | protein_coding | CA5A | No | No | 763 | P35218 |
| TVIS30041809 | HIV | ENSG00000174990.8 | protein_coding | CA5A | No | No | 763 | P35218 |
| TVIS30041810 | HIV | ENSG00000174990.8 | protein_coding | CA5A | No | No | 763 | P35218 |
| TVIS30041811 | HIV | ENSG00000174990.8 | protein_coding | CA5A | No | No | 763 | P35218 |
| TVIS20023454 | HPV | ENSG00000174990.8 | protein_coding | CA5A | No | No | 763 | P35218 |
| TVIS44008683 | HTLV-1 | ENSG00000174990.8 | protein_coding | CA5A | No | No | 763 | P35218 |
| TVIS44006283 | HTLV-1 | ENSG00000174990.8 | protein_coding | CA5A | No | No | 763 | P35218 |
| TVIS44047436 | HTLV-1 | ENSG00000174990.8 | protein_coding | CA5A | No | No | 763 | P35218 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CA5A |
|---|---|
| DrugBank ID | DB00909 |
| Drug Name | Zonisamide |
| Target ID | BE0003626 |
| UniProt ID | P35218 |
| Regulation Type | inhibitor |
| PubMed IDs | 19703035; 18537527; 15837316; 18782051; 17762320; 17582922 |
| Citations | De Simone G, Scozzafava A, Supuran CT: Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates? Chem Biol Drug Des. 2009 Sep;74(3):317-21. doi: 10.1111/j.1747-0285.2009.00857.x.@@Supuran CT, Di Fiore A, De Simone G: Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity. Expert Opin Emerg Drugs. 2008 Jun;13(2):383-92. doi: 10.1517/14728214.13.2.383 .@@De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT: Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies. Bioorg Med Chem Lett. 2005 May 2;15(9):2315-20.@@Farooq MU, Moore PW, Bhatt A, Aburashed R, Kassab MY: Therapeutic role of zonisamide in neuropsychiatric disorders. Mini Rev Med Chem. 2008 Sep;8(10):968-75.@@Biton V: Clinical pharmacology and mechanism of action of zonisamide. Clin Neuropharmacol. 2007 Jul-Aug;30(4):230-40.@@Authors unspecified: Zonisamide: new drug. No advantage in refractory partial epilepsy. Prescrire Int. 2007 Jun;16(89):95-7. |
| Groups | Approved; Investigational |
| Direct Classification | Benzisoxazoles |
| SMILES | NS(=O)(=O)CC1=NOC2=CC=CC=C12 |
| Pathways | |
| PharmGKB | PA451978 |
| ChEMBL | CHEMBL750 |
