| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS42001451 | EBV | ENSG00000198216.14 | protein_coding | CACNA1E | No | No | 777 | Q15878 |
| TVIS10032945 | HBV | ENSG00000198216.14 | protein_coding | CACNA1E | No | No | 777 | Q15878 |
| TVIS10050068 | HBV | ENSG00000198216.14 | protein_coding | CACNA1E | No | No | 777 | Q15878 |
| TVIS10041764 | HBV | ENSG00000198216.14 | protein_coding | CACNA1E | No | No | 777 | Q15878 |
| TVIS10041765 | HBV | ENSG00000198216.14 | protein_coding | CACNA1E | No | No | 777 | Q15878 |
| TVIS10041981 | HBV | ENSG00000198216.14 | protein_coding | CACNA1E | No | No | 777 | Q15878 |
| TVIS30084259 | HIV | ENSG00000198216.14 | protein_coding | CACNA1E | No | No | 777 | Q15878 |
| TVIS30087090 | HIV | ENSG00000198216.14 | protein_coding | CACNA1E | No | No | 777 | Q15878 |
| TVIS30025946 | HIV | ENSG00000198216.14 | protein_coding | CACNA1E | No | No | 777 | Q15878 |
| TVIS30025947 | HIV | ENSG00000198216.14 | protein_coding | CACNA1E | No | No | 777 | Q15878 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CACNA1E |
|---|---|
| DrugBank ID | DB00273 |
| Drug Name | Topiramate |
| Target ID | BE0008718 |
| UniProt ID | Q15878 |
| Regulation Type | antagonist |
| PubMed IDs | 27843503; 15816941; 27437073 |
| Citations | Wormuth C, Lundt A, Henseler C, Muller R, Broich K, Papazoglou A, Weiergraber M: Review: Cav2.3 R-type Voltage-Gated Ca(2+) Channels - Functional Implications in Convulsive and Non-convulsive Seizure Activity. Open Neurol J. 2016 Sep 30;10:99-126. doi: 10.2174/1874205X01610010099. eCollection 2016.@@Kuzmiski JB, Barr W, Zamponi GW, MacVicar BA: Topiramate inhibits the initiation of plateau potentials in CA1 neurons by depressing R-type calcium channels. Epilepsia. 2005 Apr;46(4):481-9. doi: 10.1111/j.0013-9580.2005.35304.x.@@Maryanoff BE: Phenotypic Assessment and the Discovery of Topiramate. ACS Med Chem Lett. 2016 Jun 13;7(7):662-5. doi: 10.1021/acsmedchemlett.6b00176. eCollection 2016 Jul 14. |
| Groups | Approved |
| Direct Classification | Dioxolopyrans |
| SMILES | [H][C@@]12CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@@]3([H])[C@]1([H])OC(C)(C)O2 |
| Pathways | |
| PharmGKB | PA451728 |
| ChEMBL | CHEMBL220492 |
