| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30077620 | HIV | ENSG00000100346.18 | protein_coding | CACNA1I | No | No | 8911 | Q9P0X4 |
| TVIS20021084 | HPV | ENSG00000100346.18 | protein_coding | CACNA1I | No | No | 8911 | Q9P0X4 |
| TVIS44018379 | HTLV-1 | ENSG00000100346.18 | protein_coding | CACNA1I | No | No | 8911 | Q9P0X4 |
| TVIS44021514 | HTLV-1 | ENSG00000100346.18 | protein_coding | CACNA1I | No | No | 8911 | Q9P0X4 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CACNA1I |
|---|---|
| DrugBank ID | DB00381 |
| Drug Name | Amlodipine |
| Target ID | BE0000012 |
| UniProt ID | Q9P0X4 |
| Regulation Type | inhibitor |
| PubMed IDs | 21910984; 25966690; 10367100; 19823601 |
| Citations | Lin M, Aladejebi O, Hockerman GH: Distinct properties of amlodipine and nicardipine block of the voltage-dependent Ca2+ channels Cav1.2 and Cav2.1 and the mutant channels Cav1.2/dihydropyridine insensitive and Cav2.1/dihydropyridine sensitive. Eur J Pharmacol. 2011 Nov 16;670(1):105-13. doi: 10.1016/j.ejphar.2011.08.005. Epub 2011 Sep 2.@@Striessnig J, Ortner NJ, Pinggera A: Pharmacology of L-type Calcium Channels: Novel Drugs for Old Targets? Curr Mol Pharmacol. 2015;8(2):110-22.@@Inoue Y, Hisatome I, Tsuboi M, Ahmmed GU, Yatsuhashi T, Uchida K, Yamanouchi Y, Santo Y, Miake J, Tanaka Y, Hamada T, Watanabe M, Igawa O, Yoshida A, Shigemasa C, Makita N, Sato R: Effects of amlodipine on native cardiac Na+ channels and cloned alpha-subunits of cardiac Na+ channels. Arzneimittelforschung. 1999 May;49(5):394-7. doi: 10.1055/s-0031-1300433.@@Ozawa Y, Hayashi K, Kobori H: New Generation Calcium Channel Blockers in Hypertensive Treatment. Curr Hypertens Rev. 2006 May 1;2(2):103-111. doi: 10.2174/157340206776877370. |
| Groups | Approved |
| Direct Classification | Dihydropyridinecarboxylic acids and derivatives |
| SMILES | CCOC(=O)C1=C(COCCN)NC(C)=C(C1C1=CC=CC=C1Cl)C(=O)OC |
| Pathways | Amlodipine Action Pathway |
| PharmGKB | PA448388 |
| ChEMBL | CHEMBL1491 |
