| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30035792 | HIV | ENSG00000134905.17 | protein_coding | CARS2 | No | No | 79587 | Q9HA77 |
| TVIS20051063 | HPV | ENSG00000134905.17 | protein_coding | CARS2 | No | No | 79587 | Q9HA77 |
| TVIS20050982 | HPV | ENSG00000134905.17 | protein_coding | CARS2 | No | No | 79587 | Q9HA77 |
| TVIS20065534 | HPV | ENSG00000134905.17 | protein_coding | CARS2 | No | No | 79587 | Q9HA77 |
| TVIS44003725 | HTLV-1 | ENSG00000134905.17 | protein_coding | CARS2 | No | No | 79587 | Q9HA77 |
| TVIS44003989 | HTLV-1 | ENSG00000134905.17 | protein_coding | CARS2 | No | No | 79587 | Q9HA77 |
| TVIS44009746 | HTLV-1 | ENSG00000134905.17 | protein_coding | CARS2 | No | No | 79587 | Q9HA77 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | CARS2 |
|---|---|
| DrugBank ID | DB00151 |
| Drug Name | Cysteine |
| Target ID | BE0002312 |
| UniProt ID | Q9HA77 |
| Regulation Type | substrate |
| PubMed IDs | 29079736; 30824121 |
| Citations | Akaike T, Ida T, Wei FY, Nishida M, Kumagai Y, Alam MM, Ihara H, Sawa T, Matsunaga T, Kasamatsu S, Nishimura A, Morita M, Tomizawa K, Nishimura A, Watanabe S, Inaba K, Shima H, Tanuma N, Jung M, Fujii S, Watanabe Y, Ohmuraya M, Nagy P, Feelisch M, Fukuto JM, Motohashi H: Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics. Nat Commun. 2017 Oct 27;8(1):1177. doi: 10.1038/s41467-017-01311-y.@@Kuo ME, Theil AF, Kievit A, Malicdan MC, Introne WJ, Christian T, Verheijen FW, Smith DEC, Mendes MI, Hussaarts-Odijk L, van der Meijden E, van Slegtenhorst M, Wilke M, Vermeulen W, Raams A, Groden C, Shimada S, Meyer-Schuman R, Hou YM, Gahl WA, Antonellis A, Salomons GS, Mancini GMS: Cysteinyl-tRNA Synthetase Mutations Cause a Multi-System, Recessive Disease That Includes Microcephaly, Developmental Delay, and Brittle Hair and Nails. Am J Hum Genet. 2019 Mar 7;104(3):520-529. doi: 10.1016/j.ajhg.2019.01.006. Epub 2019 Feb 26. |
| Groups | Approved; Nutraceutical |
| Direct Classification | Cysteine and derivatives |
| SMILES | N[C@@H](CS)C(O)=O |
| Pathways | Amiloride Action Pathway; gamma-Glutamyltranspeptidase Deficiency; 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency; Hydroflumethiazide Action Pathway; Bumetanide Action Pathway; Polythiazide Action Pathway; Ethacrynic Acid Action Pathway; Cyclothiazide Action Pathway; Trichlormethiazide Action Pathway; gamma-Glutamyltransferase Deficiency; Methionine Adenosyltransferase Deficiency; Glutamate Metabolism; Chlorothiazide Action Pathway; Pantothenate and CoA Biosynthesis; Non-Ketotic Hyperglycinemia; 2-Hydroxyglutric Aciduria (D and L Form); Indapamide Action Pathway; Hyperinsulinism-Hyperammonemia Syndrome; Iminoglycinuria; Taurine and Hypotaurine Metabolism; Glycine and Serine Metabolism; Chlorthalidone Action Pathway; Bendroflumethiazide Action Pathway; Methionine Metabolism; Eplerenone Action Pathway; Cystathionine beta-Synthase Deficiency; Glucose Transporter Defect (SGLT2); Spironolactone Action Pathway; Sarcosinemia; Quinethazone Action Pathway |
| PharmGKB | PA449173 |
| ChEMBL | CHEMBL863 |
