| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS42001416 | EBV | ENSG00000169684.13 | protein_coding | CHRNA5 | No | No | 1138 | H0YM98 P30532 Q6EWN4 |
| TVIS10020737 | HBV | ENSG00000169684.13 | protein_coding | CHRNA5 | No | No | 1138 | H0YM98 P30532 Q6EWN4 |
| TVIS10046153 | HBV | ENSG00000169684.13 | protein_coding | CHRNA5 | No | No | 1138 | H0YM98 P30532 Q6EWN4 |
| TVIS30010369 | HIV | ENSG00000169684.13 | protein_coding | CHRNA5 | No | No | 1138 | H0YM98 P30532 Q6EWN4 |
| TVIS30039126 | HIV | ENSG00000169684.13 | protein_coding | CHRNA5 | No | No | 1138 | H0YM98 P30532 Q6EWN4 |
| TVIS30039127 | HIV | ENSG00000169684.13 | protein_coding | CHRNA5 | No | No | 1138 | H0YM98 P30532 Q6EWN4 |
| TVIS30039128 | HIV | ENSG00000169684.13 | protein_coding | CHRNA5 | No | No | 1138 | H0YM98 P30532 Q6EWN4 |
| TVIS44051140 | HTLV-1 | ENSG00000169684.13 | protein_coding | CHRNA5 | No | No | 1138 | H0YM98 P30532 Q6EWN4 |
| TVIS44047313 | HTLV-1 | ENSG00000169684.13 | protein_coding | CHRNA5 | No | No | 1138 | H0YM98 P30532 Q6EWN4 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CHRNA5 |
|---|---|
| DrugBank ID | DB00184 |
| Drug Name | Nicotine |
| Target ID | BE0003586 |
| UniProt ID | P30532 |
| Regulation Type | agonist |
| PubMed IDs | 19560048; 11006350; 20400469; 20081230 |
| Citations | Mansvelder HD, Mertz M, Role LW: Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits. Semin Cell Dev Biol. 2009 Jun;20(4):432-40. doi: 10.1016/j.semcdb.2009.01.007. Epub 2009 Jan 22.@@Narahashi T, Fenster CP, Quick MW, Lester RA, Marszalec W, Aistrup GL, Sattelle DB, Martin BR, Levin ED: Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior. Toxicol Sci. 2000 Oct;57(2):193-202.@@Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, Damaj MI: Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther. 2010 Jul;334(1):137-46. doi: 10.1124/jpet.110.165738. Epub 2010 Apr 16.@@Zaniewska M, Przegalinski E, Filip M: Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives. Pharmacol Rep. 2009 Nov-Dec;61(6):957-65. |
| Groups | Approved |
| Direct Classification | Pyrrolidinylpyridines |
| SMILES | CN1CCC[C@H]1C1=CN=CC=C1 |
| Pathways | Nicotine Action Pathway; Nicotine Metabolism Pathway |
| PharmGKB | PA450626 |
| ChEMBL | CHEMBL3 |
