| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS46000413 | BKPyv | ENSG00000162368.15 | protein_coding | CMPK1 | No | No | 51727 | B2R6S5 P30085 |
| TVIS10015861 | HBV | ENSG00000162368.15 | protein_coding | CMPK1 | No | No | 51727 | B2R6S5 P30085 |
| TVIS10025821 | HBV | ENSG00000162368.15 | protein_coding | CMPK1 | No | No | 51727 | B2R6S5 P30085 |
| TVIS10020575 | HBV | ENSG00000162368.15 | protein_coding | CMPK1 | No | No | 51727 | B2R6S5 P30085 |
| TVIS20047074 | HPV | ENSG00000162368.15 | protein_coding | CMPK1 | No | No | 51727 | B2R6S5 P30085 |
| TVIS20047753 | HPV | ENSG00000162368.15 | protein_coding | CMPK1 | No | No | 51727 | B2R6S5 P30085 |
| TVIS20043035 | HPV | ENSG00000162368.15 | protein_coding | CMPK1 | No | No | 51727 | B2R6S5 P30085 |
| TVIS44035632 | HTLV-1 | ENSG00000162368.15 | protein_coding | CMPK1 | No | No | 51727 | B2R6S5 P30085 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CMPK1 |
|---|---|
| DrugBank ID | DB00441 |
| Drug Name | Gemcitabine |
| Target ID | BE0000637 |
| UniProt ID | P30085 |
| Regulation Type | inhibitor |
| PubMed IDs | 17000136; 15550676; 16041392; 17565005 |
| Citations | Vernejoul F, Ghenassia L, Souque A, Lulka H, Drocourt D, Cordelier P, Pradayrol L, Pyronnet S, Buscail L, Tiraby G: Gene therapy based on gemcitabine chemosensitization suppresses pancreatic tumor growth. Mol Ther. 2006 Dec;14(6):758-67. Epub 2006 Sep 25.@@Hsu CH, Liou JY, Dutschman GE, Cheng YC: Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase Is Differentially Regulated by ATP and Magnesium. Mol Pharmacol. 2005 Mar;67(3):806-14. Epub 2004 Nov 18.@@Maring JG, Groen HJ, Wachters FM, Uges DR, de Vries EG: Genetic factors influencing pyrimidine-antagonist chemotherapy. Pharmacogenomics J. 2005;5(4):226-43.@@Lam W, Leung CH, Bussom S, Cheng YC: The impact of hypoxic treatment on the expression of phosphoglycerate kinase and the cytotoxicity of troxacitabine and gemcitabine. Mol Pharmacol. 2007 Sep;72(3):536-44. Epub 2007 Jun 12. |
| Groups | Approved |
| Direct Classification | Pyrimidine 2'-deoxyribonucleosides |
| SMILES | NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](CO)[C@@H](O)C1(F)F |
| Pathways | Gemcitabine Metabolism Pathway; Gemcitabine Action Pathway |
| PharmGKB | PA449748 |
| ChEMBL | CHEMBL888 |
