| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30055083 | HIV | ENSG00000093010.15 | protein_coding | COMT | No | No | 1312 | P21964 |
| TVIS20014702 | HPV | ENSG00000093010.15 | protein_coding | COMT | No | No | 1312 | P21964 |
| TVIS20014703 | HPV | ENSG00000093010.15 | protein_coding | COMT | No | No | 1312 | P21964 |
| TVIS20014704 | HPV | ENSG00000093010.15 | protein_coding | COMT | No | No | 1312 | P21964 |
| TVIS20025997 | HPV | ENSG00000093010.15 | protein_coding | COMT | No | No | 1312 | P21964 |
| TVIS20034287 | HPV | ENSG00000093010.15 | protein_coding | COMT | No | No | 1312 | P21964 |
| TVIS20014705 | HPV | ENSG00000093010.15 | protein_coding | COMT | No | No | 1312 | P21964 |
| TVIS20014706 | HPV | ENSG00000093010.15 | protein_coding | COMT | No | No | 1312 | P21964 |
| TVIS20014712 | HPV | ENSG00000093010.15 | protein_coding | COMT | No | No | 1312 | P21964 |
| TVIS20014713 | HPV | ENSG00000093010.15 | protein_coding | COMT | No | No | 1312 | P21964 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | COMT |
|---|---|
| DrugBank ID | DB00118 |
| Drug Name | Ademetionine |
| Target ID | BE0002089 |
| UniProt ID | P21964 |
| Regulation Type | cofactor |
| PubMed IDs | 20196537; 18486144 |
| Citations | Lee BW, Sun HG, Zang T, Kim BJ, Alfaro JF, Zhou ZS: Enzyme-catalyzed transfer of a ketone group from an S-adenosylmethionine analogue: a tool for the functional analysis of methyltransferases. J Am Chem Soc. 2010 Mar 24;132(11):3642-3. doi: 10.1021/ja908995p.@@Rutherford K, Le Trong I, Stenkamp RE, Parson WW: Crystal structures of human 108V and 108M catechol O-methyltransferase. J Mol Biol. 2008 Jun 27;380(1):120-30. doi: 10.1016/j.jmb.2008.04.040. Epub 2008 Apr 23. |
| Groups | Approved; Investigational; Nutraceutical |
| Direct Classification | 5'-deoxy-5'-thionucleosides |
| SMILES | C[S+](CC[C@H](N)C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N |
| Pathways | Phosphatidylcholine Biosynthesis PC(14:0/20:0); Phosphatidylcholine Biosynthesis PC(14:0/20:4(5Z,8Z,11Z,14Z)); Histidinemia; Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency); Phosphatidylcholine Biosynthesis PC(14:0/20:5(5Z,8Z,11Z,14Z,17Z)); Phosphatidylcholine Biosynthesis PC(14:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)); Phosphatidylcholine Biosynthesis PC(14:0/20:2(11Z,14Z)); Tyrosine Metabolism; Disulfiram Action Pathway; Hyperprolinemia Type II; Methylhistidine Metabolism; Phosphatidylcholine Biosynthesis PC(14:0/15:0); Mercaptopurine Action Pathway; L-Arginine:Glycine Amidinotransferase Deficiency; Tyrosinemia Type I; Betaine Metabolism; Catecholamine Biosynthesis; Phenytoin (Antiarrhythmic) Action Pathway; Glycine and Serine Metabolism; Carnitine Synthesis; Phosphatidylcholine Biosynthesis PC(14:0/20:1(11Z)); Phosphatidylcholine Biosynthesis PC(14:0/22:5(4Z,7Z,10Z,13Z,16Z)); Hyperprolinemia Type I; Phosphatidylcholine Biosynthesis PC(14:0/18:2(9Z,12Z)); Phosphatidylcholine Biosynthesis PC(14:0/14:0); Histidine Metabolism; Cystathionine beta-Synthase Deficiency; Phosphatidylcholine Biosynthesis PC(14:0/16:1(9Z)); Arginine and Proline Metabolism; Sarcosine Oncometabolite Pathway |
| PharmGKB | PA164754994 |
| ChEMBL | CHEMBL1088977 |
